SRF

This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

SRF

SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation.

Biological Process actin cytoskeleton organizationISS:UniProtKB
Biological Process angiogenesis involved in wound healingManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process associative learningIEA:Ensembl
Biological Process axon extensionIEA:Ensembl
Biological Process bicellular tight junction assemblyIEA:Ensembl
Biological Process branching involved in blood vessel morphogenesisIEA:Ensembl
Biological Process bronchus cartilage developmentIEA:Ensembl
Biological Process cardiac muscle cell myoblast differentiationManual Assertion Based On ExperimentIGI:BHF-UCL
Biological Process cardiac myofibril assemblyIEA:Ensembl
Biological Process cardiac vascular smooth muscle cell differentiationIEA:Ensembl
Biological Process cell migration involved in sprouting angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cell-matrix adhesionIEA:Ensembl
Biological Process cellular response to glucose stimulusIEA:Ensembl
Biological Process cellular senescenceManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process dorsal aorta morphogenesisIEA:Ensembl
Biological Process epithelial cell-cell adhesionIEA:Ensembl
Biological Process epithelial structure maintenanceIEA:Ensembl
Biological Process erythrocyte developmentIEA:Ensembl
Biological Process eyelid development in camera-type eyeIEA:Ensembl
Biological Process face developmentIEA:Ensembl
Biological Process filopodium assemblyIEA:Ensembl
Biological Process heart developmentISS:BHF-UCL
Biological Process heart loopingISS:BHF-UCL
Biological Process heart trabecula formationIEA:Ensembl
Biological Process hematopoietic stem cell differentiationIEA:Ensembl
Biological Process hippocampus developmentIEA:Ensembl
Biological Process long-term memoryIEA:Ensembl
Biological Process long-term synaptic depressionIEA:Ensembl
Biological Process lung morphogenesisIEA:Ensembl
Biological Process lung smooth muscle developmentIEA:Ensembl
Biological Process megakaryocyte developmentIEA:Ensembl
Biological Process mesoderm formationIEA:Ensembl
Biological Process morphogenesis of an epithelial sheetIEA:Ensembl
Biological Process muscle cell cellular homeostasisISS:BHF-UCL
Biological Process negative regulation of amyloid-beta clearanceManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of cell migrationIEA:Ensembl
Biological Process negative regulation of cell population proliferationIEA:Ensembl
Biological Process negative regulation of miRNA transcriptionISS:BHF-UCL
Biological Process neuron developmentManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process neuron migrationIEA:Ensembl
Biological Process platelet activationIEA:Ensembl
Biological Process platelet formationIEA:Ensembl
Biological Process positive regulation of axon extensionIEA:Ensembl
Biological Process positive regulation of cell differentiationManual Assertion Based On ExperimentIDA:MGI
Biological Process positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of filopodium assemblyIEA:Ensembl
Biological Process positive regulation of miRNA transcriptionManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of smooth muscle contractionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of transcription by glucoseIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of transcription initiation by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive thymic T cell selectionIEA:Ensembl
Biological Process primitive streak formationIEA:Ensembl
Biological Process regulation of cell adhesionIEA:Ensembl
Biological Process regulation of smooth muscle cell differentiationManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of water loss via skinIEA:Ensembl
Biological Process response to cytokineManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process response to hormoneManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process response to hypoxiaManual Assertion Based On ExperimentIEP:BHF-UCL
Biological Process response to toxic substanceManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process sarcomere organizationIEA:Ensembl
Biological Process skin morphogenesisIEA:Ensembl
Biological Process stress fiber assemblyIEA:Ensembl
Biological Process tangential migration from the subventricular zone to the olfactory bulbIEA:Ensembl
Biological Process thymus developmentIEA:Ensembl
Biological Process thyroid gland developmentIEA:Ensembl
Biological Process trachea cartilage developmentIEA:Ensembl
Biological Process transcription by RNA polymerase IIIEA:Ensembl
Biological Process trophectodermal cell differentiationManual Assertion Based On ExperimentIDA:MGI

Nucleus

Phosphorylated by PRKDC.