SPRY2

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

Sprouty RTK Signaling Antagonist 2

Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity).
Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity).
Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity).
Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561).

Biological Process animal organ developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process bud elongation involved in lung branchingIEA:Ensembl
Biological Process cell fate commitmentIEA:Ensembl
Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process cellular response to vascular endothelial growth factor stimulusManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process ERK1 and ERK2 cascadeIEA:Ensembl
Biological Process establishment of mitotic spindle orientationIEA:Ensembl
Biological Process fibroblast growth factor receptor signaling pathwayIEA:Ensembl
Biological Process inner ear morphogenesisIEA:Ensembl
Biological Process lung growthIEA:Ensembl
Biological Process negative regulation of angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of cell population proliferationIEA:Ensembl
Biological Process negative regulation of cell projection organizationISS:BHF-UCL
Biological Process negative regulation of epithelial to mesenchymal transitionISS:UniProtKB
Biological Process negative regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of GTPase activityIEA:Ensembl
Biological Process negative regulation of lens fiber cell differentiationISS:UniProtKB
Biological Process negative regulation of MAP kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of neurotrophin TRK receptor signaling pathwayIEA:Ensembl
Biological Process negative regulation of peptidyl-threonine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwayISS:UniProtKB
Biological Process negative regulation of vascular endothelial growth factor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process sensory perception of soundIEA:Ensembl

Cytoplasm, cytoskeleton
Cell projection, ruffle membrane
Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor).

IgA nephropathy 3 (IGAN3):
A form of IgA nephropathy, a common primary glomerulonephritis characterized by glomerular sclerosis, interstitial fibrosis, and mesangial glomerular deposits of immunoglobulin A and immunoglobulin G visible on renal biopsies. IgA nephropathy is associated with renal insufficiency that can progress to end-stage renal disease. Proteinuria and hematuria are characteristic clinical presentations.

Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro).