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SPC24

SPC24 (SPC24, NDC80 Kinetochore Complex Component) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Cell Cycle, Mitotic.
Full Name
SPC24, NDC80 Kinetochore Complex Component
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735).
Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735).
The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).
Biological Process
Biological Process attachment of spindle microtubules to kinetochoreManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process chromosome segregationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitotic spindle assembly checkpoint signaling1 PublicationIC:ComplexPortal
Cellular Location
Nucleus
Chromosome, centromere, kinetochore
Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.

Anti-SPC24 antibodies

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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
Target: SPC24
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1285
Application*: WB, IP, IF
Target: SPC24
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1284
Application*: WB, IP, IF
Target: SPC24
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4330
Application*: WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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