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SOX8

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). [provided by RefSeq]
Full Name
SRY (sex determining region Y)-box 8
Function
Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity).
Biological Process
Biological Process adipose tissue developmentISS:UniProtKB
Biological Process astrocyte fate commitmentIEA:Ensembl
Biological Process cell fate commitmentISS:UniProtKB
Biological Process cell maturationIEA:Ensembl
Biological Process enteric nervous system developmentISS:UniProtKB
Biological Process fat cell differentiationISS:UniProtKB
Biological Process in utero embryonic developmentISS:UniProtKB
Biological Process male gonad developmentISS:UniProtKB
Biological Process metanephric nephron tubule formationISS:UniProtKB
Biological Process morphogenesis of a branching epitheliumISS:UniProtKB
Biological Process morphogenesis of an epitheliumManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of apoptotic processISS:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process negative regulation of myoblast differentiationISS:UniProtKB
Biological Process negative regulation of photoreceptor cell differentiationIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationISS:UniProtKB
Biological Process oligodendrocyte differentiationISS:UniProtKB
Biological Process osteoblast differentiationISS:UniProtKB
Biological Process peripheral nervous system developmentISS:UniProtKB
Biological Process positive regulation of branching involved in ureteric bud morphogenesisISS:UniProtKB
Biological Process positive regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process positive regulation of gliogenesisISS:UniProtKB
Biological Process positive regulation of kidney developmentISS:UniProtKB
Biological Process positive regulation of osteoblast proliferationISS:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of hormone levelsISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process renal vesicle inductionISS:UniProtKB
Biological Process retina development in camera-type eyeISS:UniProtKB
Biological Process retinal rod cell differentiationISS:UniProtKB
Biological Process Sertoli cell developmentISS:UniProtKB
Biological Process signal transductionISS:UniProtKB
Biological Process skeletal muscle cell differentiationIEA:Ensembl
Biological Process spermatogenesisISS:UniProtKB
Biological Process ureter morphogenesisISS:UniProtKB
Cellular Location
Nucleus

Anti-SOX8 antibodies

+ Filters
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Target: SOX8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1F4
Application*: IP, M, WB
Target: SOX8
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 2B9
Application*: IP, E
Target: SOX8
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 2C6
Application*: IP, E
Target: SOX8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D11
Application*: IP, E, WB
Target: SOX8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 8D8
Application*: WB, E
Target: SOX8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 8G7
Application*: WB, E
Target: SOX8
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2013
Application*: WB, IP, IF, E
Target: SOX8
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2298
Application*: WB, IP, IF, E
Target: SOX8
Host: Mouse
Specificity: Human
Clone: CBXS-3458
Application*: E, IF, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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