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SLC3A2

This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]
Full Name
Solute Carrier Family 3 Member 2
Function
Component of several heterodimeric complexes involved in amino acid transport (PubMed:11557028, PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:30341327).
The precise substrate specificity depends on the other subunit in the heterodimer (PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:30867591, PubMed:10903140).
The complexes function as amino acid exchangers (PubMed:11557028, PubMed:10903140, PubMed:12117417, PubMed:12225859, PubMed:30867591).
The homodimer functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:11557028, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591).
The heterodimer formed by SLC3A2 and SLC7A6 or SLC3A2 and SLC7A7 mediates the uptake of dibasic amino acids (PubMed:9829974, PubMed:10903140).
The heterodimer with SLC7A5/LAT1 mediates the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859).
The heterodimer with SLC7A5/LAT1 is involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417).
The heterodimer with SLC7A5/LAT1 is involved in the uptake of leucine (PubMed:25998567, PubMed:30341327).
When associated with LAPTM4B, the heterodimer with SLC7A5/LAT1 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567).
The heterodimer with SLC7A5/LAT1 may play a role in the transport of L-DOPA across the blood-brain barrier (By similarity).
The heterodimer formed by SLC3A2 and SLC7A5/LAT1 or SLC3A2 and SLC7A8/LAT2 is involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (PubMed:15769744).
Together with ICAM1, regulates the transport activity of SLC7A8/LAT2 in polarized intestinal cells by generating and delivering intracellular signals (PubMed:12716892).
Required for targeting of SLC7A5/LAT1 and SLC7A8/LAT2 to the plasma membrane and for channel activity (PubMed:9751058, PubMed:11311135, PubMed:30867591).
Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine (PubMed:14603368).
May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity).
(Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis.
Biological Process
Biological Process amino acid transportManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process calcium ion transport1 PublicationNAS:UniProtKB
Biological Process carbohydrate metabolic processIEA:InterPro
Biological Process L-alanine import across plasma membraneManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process L-leucine import across plasma membraneManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process leucine import across plasma membraneManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process leucine transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process phenylalanine transportManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process response to exogenous dsRNAManual Assertion Based On ExperimentIMP:MGI
Biological Process tryptophan transportISS:UniProtKB
Biological Process viral entry into host cellManual Assertion Based On ExperimentIMP:UniProtKB
Topology
Cytoplasmic: 102-184
Helical: 185-205
Extracellular: 206-630
PTM
Phosphorylation on Ser-406; Ser-408 or Ser-410 and on Ser-527 or Ser-531 by ecto-protein kinases favors heterotypic cell-cell interactions.

Anti-SLC3A2 antibodies

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Target: SLC3A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D6O3P
Application*: WB, IP, IF (IC), F
Target: SLC3A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D5U4G
Application*: WB, P, IF (IC)
Target: SLC3A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D3F9D
Application*: WB, P, IF (IC), F
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: n.a
Application*: C, IP, F
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-705
Application*: IH, IP, FC, P
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 9L813
Application*: FC
Target: SLC3A2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: RL388
Application*: F, IP
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: YUK14
Application*: F
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: LG.3A10
Application*: F
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0477
Application*: F, IH
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0476
Application*: F, C, P, IP
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0475
Application*: P, C, IP
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5560
Application*: F, FN
Target: SLC3A2
Host: Rabbit
Specificity: Human, Monkey
Clone: CBXS-5425
Application*: WB, IP, IF, F
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5652
Application*: F, C, P, IP
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 30/CD98HC
Application*: WB, IF
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0741
Application*: F, IH, IP
Target: SLC3A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-3129
Application*: P
Target: SLC3A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-3128
Application*: E
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-0378
Application*: WB, F, IH, P
Target: SLC3A2
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 10B2165
Application*: F
Target: SLC3A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 048
Application*: P
Target: SLC3A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 021
Application*: E
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 7H227
Application*: F
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 590559
Application*: F, IC, MC
Target: SLC3A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 071
Application*: P
Target: SLC3A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 065
Application*: E
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 44D7
Application*: F, C, IP
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1783
Application*: F, IH, IP
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1C11.7E3
Application*: WB, F, IH, P
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Rat, Mouse
Clone: CBWJC-4448
Application*: WB, E, IP
Target: SLC3A2
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBWJC-4446
Application*: IP, IF, E
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJC-4444
Application*: F, C
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-4443
Application*: F
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-4442
Application*: F
Target: SLC3A2
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: H202-529.4.1.4
Application*: F
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2409
Application*: F
Target: SLC3A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-4955
Application*: P
Target: SLC3A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-4261
Application*: E
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0692
Application*: F, P, IP
Target: SLC3A2
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-1394
Application*: F
Target: SLC3A2
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0835
Application*: F
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1258
Application*: F
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: UM7F8
Application*: WB, F, IF, IP, C, MC
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-108
Application*: F, IH, IP, P, F, MC
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: IPO-T10
Application*: F, IF
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-2490
Application*: WB, F, IH, P
Target: SLC3A2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C0362
Application*: F
Target: SLC3A2
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYC-3131
Application*: F
Target: SLC3A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-3127
Application*: P
Target: SLC3A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-3126
Application*: E
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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