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SLC1A2

This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq]
Full Name
solute carrier family 1 (glial high affinity glutamate transporter), member 2
Function
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923).
Functions as a symporter that transports one amino acid molecule together with two or three Na+ ions and one proton, in parallel with the counter-transport of one K+ ion (PubMed:14506254).
Mediates Cl- flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na+ symport (PubMed:14506254).
Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).
Biological Process
Biological Process adult behaviorIEA:Ensembl
Biological Process cellular response to cocaineIEA:Ensembl
Biological Process cellular response to extracellular stimulusIEA:Ensembl
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process D-aspartate import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glutathione biosynthetic processIEA:Ensembl
Biological Process ion transportTAS:Reactome
Biological Process L-aspartate import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-aspartate transmembrane transportISS:ARUK-UCL
Biological Process L-glutamate import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-glutamate transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process multicellular organism agingIEA:Ensembl
Biological Process multicellular organism growthIEA:Ensembl
Biological Process neurotransmitter reuptakeIEA:Ensembl
Biological Process neurotransmitter transportTAS:Reactome
Biological Process positive regulation of glucose importIEA:Ensembl
Biological Process protein homotrimerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to amino acidIEA:Ensembl
Biological Process response to woundingIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process telencephalon developmentIEA:Ensembl
Biological Process transepithelial transportISS:ARUK-UCL
Biological Process transport across blood-brain barrierISS:ARUK-UCL
Biological Process visual behaviorIEA:Ensembl
Cellular Location
Cell membrane
Involvement in disease
Developmental and epileptic encephalopathy 41 (DEE41):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE41 inheritance is autosomal dominant.
Topology
Cytoplasmic: 1-44
Helical: 45-64
Extracellular: 65-87
Helical: 88-108
Cytoplasmic: 109-120
Helical: 121-142
Extracellular: 143-235
Helical: 236-259
Cytoplasmic: 260-268
Helical: 269-296
Extracellular: 297-317
Helical: 318-339
Cytoplasmic: 340-344
Helical: 345-375
Extracellular: 376-384
Helical: 385-411
Cytoplasmic: 412-424
Helical: 425-458
Extracellular: 459-471
Helical: 472-493
Cytoplasmic: 494-574
PTM
Glycosylated.
Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity.

Anti-SLC1A2 antibodies

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Target: SLC1A2
Host: Mouse
Specificity: Human
Clone: CBXS-3252
Application*: E, WB
Target: SLC1A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-0435
Application*: P
Target: SLC1A2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0434
Application*: IC, P, WB
Target: SLC1A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4241
Application*: P
Target: SLC1A2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-4017
Application*: E, WB
Target: SLC1A2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G8
Application*: WB, E
Target: SLC1A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5G109
Application*: IH
Target: SLC1A2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 10H26
Application*: IC, IH, WB
Target: SLC1A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-1647
Application*: WB, E, P
Target: SLC1A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 20/EAAT2
Application*: WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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