SLC17A6

Solute Carrier Family 17 Member 6; Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 6; Differentiation-Associated Na(+)-Dependent Inorganic Phosphate Cotransporter; Differentiation-Associated Na-Dependent Inorganic Phosphate Cotransporter; Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 6; Vesicular Glutamate Transporter 2; Differentiation-Associated BNPI; VGLUT2; DNPI;

Solute Carrier Family 17 Member 6

Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:33440152, PubMed:11698620).
At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:11698620).
The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H+-ATPase across the synaptic vesicle membrane (PubMed:11698620).
In addition, functions as a chloride channel that allows the chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity).
Moreover, functions as a vesicular K+/H+ antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity).
The vesicular H+/H+ antiport activity is electroneutral (By similarity).
At the plasma membrane, following exocytosis, functions as a symporter of Na+ and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (Probable) (PubMed:10820226).
The symporter activity is driven by an inside negative membrane potential and is electrogenic (Probable). Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (By similarity).
May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas (By similarity).

Biological Process anion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process hyaloid vascular plexus regressionISS:UniProtKB
Biological Process ion transportTAS:Reactome
Biological Process L-glutamate importManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process neurotransmitter loading into synaptic vesicleManual Assertion Based On ExperimentIMP:SynGO
Biological Process phosphate ion homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process phosphate ion transportISS:UniProtKB
Biological Process regulation of synapse structure or activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sodium-dependent phosphate transportISS:UniProtKB
Biological Process synaptic transmission, glutamatergicManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Annotation
Synapse, synaptosome
Cell membrane

Cytoplasmic: 1-71
Helical: 72-92
Vesicular: 93-125
Helical: 126-146
Cytoplasmic: 147-148
Helical: 149-169
Vesicular: 170-177
Helical: 178-198
Cytoplasmic: 199-216
Helical: 217-237
Vesicular: 238-244
Helical: 245-265
Cytoplasmic: 266-310
Helical: 311-331
Vesicular: 332-349
Helical: 350-370
Cytoplasmic: 371-386
Helical: 387-407
Vesicular: 408-409
Helical: 410-430
Cytoplasmic: 431-443
Helical: 444-464
Vesicular: 465-477
Helical: 478-498
Cytoplasmic: 499-582