SIRPA

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

signal regulatory protein alpha

Signal Regulatory Protein Alpha; CD172 Antigen-Like Family Member A; Inhibitory Receptor SHPS-1; Macrophage Fusion Receptor; PTPNS1; SHPS1; SIRP; P84; BIT; MFR; Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs; Brain Ig-Like Molecule With Tyrosine-Based Activation Motifs; Protein Tyrosine Phosphatase; Non-Receptor Type Substrate 1; Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1; Tyrosine Phosphatase SHP Substrate 1; Signal-Regulatory Protein Alpha-1;

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity).
Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cell migrationISS:ARUK-UCL
Biological Process cellular response to hydrogen peroxideISS:ARUK-UCL
Biological Process cellular response to interferon-gammaISS:ARUK-UCL
Biological Process cellular response to interleukin-1ISS:ARUK-UCL
Biological Process cellular response to interleukin-12Manual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process cellular response to lipopolysaccharideISS:ARUK-UCL
Biological Process monocyte extravasationISS:ARUK-UCL
Biological Process negative regulation of chemokine (C-C motif) ligand 5 productionISS:ARUK-UCL
Biological Process negative regulation of cytokine production involved in inflammatory responseISS:ARUK-UCL
Biological Process negative regulation of ERK1 and ERK2 cascadeISS:ARUK-UCL
Biological Process negative regulation of I-kappaB phosphorylationISS:ARUK-UCL
Biological Process negative regulation of inflammatory responseManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of interferon-beta productionISS:ARUK-UCL
Biological Process negative regulation of interleukin-6 productionISS:ARUK-UCL
Biological Process negative regulation of JNK cascadeISS:ARUK-UCL
Biological Process negative regulation of macrophage inflammatory protein 1 alpha productionISS:ARUK-UCL
Biological Process negative regulation of nitric oxide biosynthetic processISS:ARUK-UCL
Biological Process negative regulation of phagocytosisISS:ARUK-UCL
Biological Process negative regulation of protein phosphorylationISS:ARUK-UCL
Biological Process negative regulation of tumor necrosis factor productionISS:ARUK-UCL
Biological Process positive regulation of phagocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process regulation of interleukin-1 beta productionISS:ARUK-UCL
Biological Process regulation of interleukin-6 productionISS:ARUK-UCL
Biological Process regulation of nitric oxide biosynthetic processISS:ARUK-UCL
Biological Process regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIGI:ARUK-UCL

Membrane

Extracellular: 31-373
Helical: 374-394
Cytoplasmic: 395-504

N-glycosylated.
Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.