SH3GL2

SH3GL2 implicated in synaptic vesicle endocytosis and may recruit other proteins to membranes with high curvature. SH3GL2 required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.

SH3-domain GRB2-like 2

Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.

Biological Process cellular response to brain-derived neurotrophic factor stimulusISS:UniProtKB
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process dendrite extensionISS:UniProtKB
Biological Process negative regulation of blood-brain barrier permeabilityManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process neuron projection developmentISS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process synaptic vesicle uncoatingManual Assertion Based On ExperimentIBA:GO_Central