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Rabbit Anti-SH3GL2 Recombinant Antibody (CBFYE-1645) (CBMAB-E2311-FY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBFYE-1645
Application
IF, IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues surrounding Gly268 of human Endophilin-1
Specificity
Human, Mouse
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10mM Sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SH3-domain GRB2-like 2
Introduction
The molecular mechanism of EGFR protein overexpression, we analyze the alterations of EGFR, SH3GL2 and CDC25A in the same set of HNSCC samples.
Entrez Gene ID
Human6456
Mouse20404
UniProt ID
HumanQ99962
MouseQ62420
Alternative Names
SH3 Domain Containing GRB2 Like 2, Endophilin A1; SH3 Domain-Containing GRB2-Like Protein 2; SH3 Domain Protein 2A; Endophilin-A1; Endophilin-1; EEN-B1; SH3D2A
Function
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Biological Process
Biological Process cellular response to brain-derived neurotrophic factor stimulusISS:UniProtKB
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process dendrite extensionISS:UniProtKB
Biological Process negative regulation of blood-brain barrier permeabilityManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process neuron projection developmentISS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process synaptic vesicle uncoatingManual Assertion Based On ExperimentIBA:GO_Central
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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