SFRP1

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]

Secreted Frizzled Related Protein 1

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity).
Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity).
In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity).
Inhibits WNT1/WNT4-mediated TCF-dependent transcription.

Biological Process BMP signaling pathwayIEA:Ensembl
Biological Process bone trabecula formationIEA:Ensembl
Biological Process canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process cellular response to BMP stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to estradiol stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to estrogen stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to fibroblast growth factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to growth factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to heparinManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to hypoxiaManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to interleukin-1Manual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to prostaglandin E stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to starvationManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to transforming growth factor beta stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to tumor necrosis factorManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to vitamin DManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to X-rayIEA:Ensembl
Biological Process convergent extension involved in somitogenesisIEA:Ensembl
Biological Process digestive tract morphogenesisIEA:Ensembl
Biological Process dopaminergic neuron differentiationIEA:Ensembl
Biological Process dorsal/ventral axis specificationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process extrinsic apoptotic signaling pathwayIEA:Ensembl
Biological Process female gonad developmentIEA:Ensembl
Biological Process hematopoietic progenitor cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process hematopoietic stem cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process male gonad developmentIEA:Ensembl
Biological Process negative regulation of androgen receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of B cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of BMP signaling pathwayIEA:Ensembl
Biological Process negative regulation of bone remodelingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell growthManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of epithelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of epithelial to mesenchymal transitionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of fibroblast apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of fibroblast proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of gene expressionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of insulin secretionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of JUN kinase activityIEA:Ensembl
Biological Process negative regulation of ossificationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of osteoblast differentiationIEA:Ensembl
Biological Process negative regulation of osteoblast proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of osteoclast differentiationIEA:Ensembl
Biological Process negative regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of planar cell polarity pathway involved in axis elongationIEA:Ensembl
Biological Process negative regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specificationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neural crest cell fate commitmentIEA:Ensembl
Biological Process osteoblast differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process osteoclast differentiationIEA:Ensembl
Biological Process planar cell polarity pathway involved in axis elongationIEA:Ensembl
Biological Process planar cell polarity pathway involved in neural tube closureIEA:Ensembl
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cell growthManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cell-matrix adhesionISS:BHF-UCL
Biological Process positive regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of epithelial cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of fat cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of fibroblast apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of focal adhesion assemblyISS:BHF-UCL
Biological Process positive regulation of GTPase activityISS:BHF-UCL
Biological Process positive regulation of non-canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of smoothened signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of stress fiber assemblyISS:BHF-UCL
Biological Process positive regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisIEA:Ensembl
Biological Process regulation of angiogenesisISS:BHF-UCL
Biological Process regulation of branching involved in prostate gland morphogenesisIEA:Ensembl
Biological Process regulation of cell cycle processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of midbrain dopaminergic neuron differentiationIEA:Ensembl
Biological Process regulation of neuron projection developmentIEA:Ensembl
Biological Process response to organic cyclic compoundManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process somatic stem cell population maintenanceIEA:Ensembl
Biological Process stromal-epithelial cell signaling involved in prostate gland developmentIEA:Ensembl
Biological Process ureteric bud developmentIEA:Ensembl
Biological Process Wnt signaling pathway involved in somitogenesisIEA:Ensembl

Secreted
Cell membrane or extracellular matrix-associated. Released by heparin-binding.