SEMA4D

SEMA4D (Semaphorin 4D) is a Protein Coding gene. Diseases associated with SEMA4D include Hemorrhagic Fever With Renal Syndrome and Osteonecrosis Of The Jaw. Among its related pathways are Development Slit-Robo signaling and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include receptor binding and transmembrane signaling receptor activity. An important paralog of this gene is SEMA4C.

Semaphorin 4D

Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282).
Regulates GABAergic synapse development (By similarity).
Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity).
Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569).
Promotes the migration of cerebellar granule cells (PubMed:16055703).
Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214).
Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703).

Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process immune responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process leukocyte aggregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of alkaline phosphatase activityManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of osteoblast differentiationISS:BHF-UCL
Biological Process negative regulation of peptidyl-tyrosine phosphorylationISS:BHF-UCL
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ossification involved in bone maturationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of collateral sproutingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of inhibitory synapse assemblyISS:UniProtKB
Biological Process positive regulation of peptidyl-tyrosine phosphorylationISS:BHF-UCL
Biological Process positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of cell projection organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell shapeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of dendrite morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process semaphorin-plexin signaling pathway involved in bone trabecula morphogenesisISS:BHF-UCL

Cell membrane

Extracellular: 22-734
Helical: 735-755
Cytoplasmic: 756-862