SEMA3A

This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.

Semaphorin 3A

Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.

Biological Process apoptotic processIEA:Ensembl
Biological Process axon extension involved in axon guidanceISS:BHF-UCL
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process axonogenesis involved in innervationISS:BHF-UCL
Biological Process basal dendrite arborizationBy SimilarityISS:ARUK-UCL
Biological Process motor neuron axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of neuron projection developmentManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process nerve developmentISS:BHF-UCL
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migration involved in autonomic nervous system developmentISS:BHF-UCL
Biological Process neuron migrationISS:BHF-UCL
Biological Process olfactory bulb developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of JNK cascadeManual Assertion Based On ExperimentTAS:ARUK-UCL
Biological Process positive regulation of neuron migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process semaphorin-plexin signaling pathway involved in neuron projection guidanceISS:BHF-UCL
Biological Process sensory system developmentManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process sympathetic ganglion developmentISS:BHF-UCL
Biological Process sympathetic nervous system developmentManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process sympathetic neuron projection extensionISS:BHF-UCL
Biological Process sympathetic neuron projection guidanceISS:BHF-UCL

Secreted

Hypogonadotropic hypogonadism 16 with or without anosmia (HH16):
A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).