RUVBL2

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008]

RuvB Like AAA ATPase 2

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868, PubMed:33205750).
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270).
This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270).
This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270).
The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270).
NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270).
Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511).
Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910).
Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379).
May also inhibit the transcriptional activity of ATF2 (PubMed:11713276).
Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260).
May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026).

Biological Process box C/D snoRNP assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to estradiol stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to UVManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process chromatin remodelingManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process DNA recombinationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process DNA repairManual Assertion Based On ExperimentTAS:ProtInc
Biological Process establishment of protein localization to chromatinManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process histone acetylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process histone exchange1 PublicationIC:ComplexPortal
Biological Process histone H2A acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process histone H4 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process positive regulation of double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process positive regulation of histone acetylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of telomerase RNA localization to Cajal bodyManual Assertion Based On ExperimentHMP:BHF-UCL
Biological Process positive regulation of telomere maintenance in response to DNA damageIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein foldingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein stabilization3 PublicationsIC:ComplexPortal
Biological Process regulation of apoptotic process1 PublicationIC:ComplexPortal
Biological Process regulation of cell cycleManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process regulation of chromosome organizationManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process regulation of DNA replicationManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process regulation of DNA strand elongationManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process regulation of DNA-templated transcription1 PublicationIC:ComplexPortal
Biological Process regulation of double-strand break repair1 PublicationIC:ComplexPortal
Biological Process regulation of embryonic developmentIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process telomere maintenanceIEA:Ensembl

Nucleus matrix
Nucleus, nucleoplasm
Cytoplasm
Membrane
Dynein axonemal particle
Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol. Although it is also present in the cytoplasm and associated with the cell membranes.