RGCC

This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression.

Full Name

RGCC

Function

Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.

Biological Process

Biological Process cell cycleIEA:UniProtKB-KW
Biological Process cellular response to hypoxiaManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process complement activationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process fibroblast activationISS:UniProtKB
Biological Process negative regulation of angiogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of blood vessel endothelial cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of cell-cell adhesion mediated by cadherinManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of cytokine productionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of endothelial cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of exit from mitosisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of fibroblast growth factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of mitotic cell cycle phase transitionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of collagen biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of cyclin-dependent protein serine/threonine kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of cytokine productionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of DNA biosynthetic processISS:BHF-UCL
Biological Process positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of endothelial cell apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of epithelial to mesenchymal transitionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of extracellular matrix assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of extracellular matrix constituent secretionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of mitotic nuclear divisionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of stress fiber assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Cytoplasm
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase.