RAC2

This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]

Rac Family Small GTPase 2

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.

Biological Process actin filament organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell projection assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cortical cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process engulfment of apoptotic cellManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process lymphocyte aggregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mast cell proliferationIEA:Ensembl
Biological Process motor neuron axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of lamellipodium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of mast cell proliferationIEA:Ensembl
Biological Process positive regulation of neutrophil chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL
Biological Process Rac protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell-substrate adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of hydrogen peroxide metabolic processManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of mast cell chemotaxisIEA:Ensembl
Biological Process regulation of mast cell degranulationIEA:Ensembl
Biological Process regulation of neutrophil migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of respiratory burstManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of T cell proliferationIEA:Ensembl
Biological Process respiratory burst1 PublicationIC:ComplexPortal
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cytoplasm
Membrane-associated when activated.

Immunodeficiency 73A with defective neutrophil chemotaxis and leukocytosis (IMD73A):
An autosomal dominant immunologic disorder characterized by onset of recurrent infections in early infancy, leukocytosis, neutrophilia, invasive infections, and poor wound healing.
Immunodeficiency 73B with defective neutrophil chemotaxis and lymphopenia (IMD73B):
An autosomal dominant immunologic disorder characterized by respiratory infections, cellulitis, severe invasive infections, B- and T-cell lymphopenia, and impaired neutrophil chemotaxis. Disease onset is in infancy or early childhood.
Immunodeficiency 73C with defective neutrophil chemotaxis and hypogammaglobulinemia (IMD73C):
An autosomal recessive immunologic disorder characterized by recurrent respiratory infections, decreased B cells, hypogammaglobulinemia, and impaired neutrophil chemotaxis. Variable features are urticaria, recurrent erythematous plaques, food allergy, arthralgia, bronchiectasis, and lymphadenopathy. In addition, patients suffer from glomerulonephritis, coagulopathy, multiple hormone deficiencies, and abnormalities of neutrophil granules.

(Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly.