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Mouse Anti-RAC2 Recombinant Antibody (3B8) (CBMAB-R1005-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B8
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa. 1-193 from human RAC2 (H01485) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
Rac Family Small GTPase 2
Introduction
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]
Entrez Gene ID
5880
UniProt ID
P15153
Alternative Names
Rac Family Small GTPase 2; Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2); Small G Protein; P21-Rac2; Gx; Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP-Binding Protein Rac2); Ras-Related C3 Botulinum Toxin Substrate 2; HSPC022; EN-7;
Function
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Biological Process
Biological Process actin filament organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell projection assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cortical cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process engulfment of apoptotic cellManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process lymphocyte aggregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mast cell proliferationIEA:Ensembl
Biological Process motor neuron axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of lamellipodium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of mast cell proliferationIEA:Ensembl
Biological Process positive regulation of neutrophil chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL
Biological Process Rac protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell-substrate adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of hydrogen peroxide metabolic processManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of mast cell chemotaxisIEA:Ensembl
Biological Process regulation of mast cell degranulationIEA:Ensembl
Biological Process regulation of neutrophil migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of respiratory burstManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of T cell proliferationIEA:Ensembl
Biological Process respiratory burst1 PublicationIC:ComplexPortal
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Membrane-associated when activated.
Involvement in disease
Immunodeficiency 73A with defective neutrophil chemotaxis and leukocytosis (IMD73A):
An autosomal dominant immunologic disorder characterized by onset of recurrent infections in early infancy, leukocytosis, neutrophilia, invasive infections, and poor wound healing.
Immunodeficiency 73B with defective neutrophil chemotaxis and lymphopenia (IMD73B):
An autosomal dominant immunologic disorder characterized by respiratory infections, cellulitis, severe invasive infections, B- and T-cell lymphopenia, and impaired neutrophil chemotaxis. Disease onset is in infancy or early childhood.
Immunodeficiency 73C with defective neutrophil chemotaxis and hypogammaglobulinemia (IMD73C):
An autosomal recessive immunologic disorder characterized by recurrent respiratory infections, decreased B cells, hypogammaglobulinemia, and impaired neutrophil chemotaxis. Variable features are urticaria, recurrent erythematous plaques, food allergy, arthralgia, bronchiectasis, and lymphadenopathy. In addition, patients suffer from glomerulonephritis, coagulopathy, multiple hormone deficiencies, and abnormalities of neutrophil granules.
PTM
(Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly.
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For research use only. Not intended for any clinical use.

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