PYM1

PYM1 (PYM Homolog 1, Exon Junction Complex Associated Factor) is a protein-coding gene. Among its related pathways are RNA transport and mRNA surveillance pathway.

PYM homolog 1, exon junction complex associated factor

Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.

Biological Process exon-exon junction complex disassemblyManual Assertion Based On ExperimentIDA:HGNC
Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of translationManual Assertion Based On ExperimentIDA:UniProtKB

Cytoplasm
Nucleus, nucleolus
Nucleus, nucleoplasm
Shuttles between the nucleus and the cytoplasm (PubMed:14968132).
Nuclear export is mediated by XPO1/CRM1 (PubMed:14968132).