PTS

PTS catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity.

Full Name

6-pyruvoyltetrahydropterin synthase

Function

Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

Biological Process

Cellular amino acid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Tetrahydrobiopterin biosynthetic processManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

cytoplasm
cytosol
mitochondrion

Involvement in disease

Hyperphenylalaninemia, BH4-deficient, A (HPABH4A):
An autosomal recessive disorder characterized by hyperphenylalaninemia, depletion of the neurotransmitters dopamine and serotonin, and progressive cognitive and motor deficits. Neurological symptoms are unresponsive to the classic phenylalanine-low diet.

PTM

Phosphorylation of Ser-19 is required for maximal enzyme activity.

Anti-PTS antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-PTS Recombinant Antibody (AT2B2) (CBMAB-1741-CN)

Datasheet

SDS

Target: PTS

Host: Mouse

Antibody Isotype: IgG2b, λ

Specificity: Human, Mouse

Clone: AT2B2

Application*: E, WB

Mouse Anti-PTS Recombinant Antibody (D-8) (CBMAB-P3502-YC)

Datasheet

SDS

Target: PTS

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: D-8

Application*: WB, IP, IF, E

Mouse Anti-PTS Recombinant Antibody (2B2) (CBMAB-P3501-YC)

Datasheet

SDS

Target: PTS

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse

Clone: 2B2

Application*: WB, E

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)