PTPRZ1

PTPRZ1 is a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS.

Protein tyrosine phosphatase, receptor type Z1

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).

AxonogenesisIEA:Ensembl
Central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Hematopoietic progenitor cell differentiationIEA:Ensembl
Learning or memoryISS:UniProtKB
Negative regulation of neuron apoptotic processISS:UniProtKB
Oligodendrocyte differentiationISS:UniProtKB
Peptidyl-tyrosine dephosphorylationISS:UniProtKB
Positive regulation of oligodendrocyte differentiationISS:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of myelinationISS:UniProtKB
Regulation of oligodendrocyte progenitor proliferationISS:UniProtKB

Isoform 1
Cell membrane
Secreted
A secreted form is apparently generated by shedding of the extracellular domain.
Isoform 2
Secreted

Extracellular: 25-1636
Helical: 1637-1662
Cytoplasmic: 1663-2315