PTPN6

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

PTPN6

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

Abortive mitotic cell cycleIEA:Ensembl
B cell receptor signaling pathwayIEA:Ensembl
Cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Cytokine-mediated signaling pathwayTAS:Reactome
Epididymis developmentIEA:Ensembl
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Hematopoietic progenitor cell differentiationIEA:Ensembl
Intracellular signal transductionIEA:Ensembl
Megakaryocyte developmentIEA:Ensembl
Natural killer cell mediated cytotoxicityIEA:Ensembl
Negative regulation of cell population proliferation1 PublicationNAS:UniProtKB
Negative regulation of humoral immune response mediated by circulating immunoglobulinIEA:Ensembl
Negative regulation of interleukin-6 productionISS:ARUK-UCL
Negative regulation of MAP kinase activityIEA:Ensembl
Negative regulation of mast cell activation involved in immune responseIEA:Ensembl
Negative regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of T cell proliferationIEA:Ensembl
Negative regulation of T cell receptor signaling pathwayIEA:Ensembl
Negative regulation of tumor necrosis factor productionISS:ARUK-UCL
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Platelet aggregationIEA:Ensembl
Platelet formationIEA:Ensembl
Positive regulation of cell adhesion mediated by integrinIEA:Ensembl
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIMP:BHF-UCL
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Regulation of B cell differentiationIEA:Ensembl
Regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of release of sequestered calcium ion into cytosolIEA:Ensembl
Regulation of type I interferon-mediated signaling pathwayTAS:Reactome
T cell costimulationTAS:Reactome

Cytoplasm
Nucleus
In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity).
Shuttles between the cytoplasm and nucleus via its association with PDPK1

Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity).
Phosphorylation at Tyr-564 enhances phosphatase activity.