PPARA

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.

PPARA

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

Behavioral response to nicotineIEA:Ensembl
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to starvationISS:ARUK-UCL
Circadian regulation of gene expressionISS:UniProtKB
Enamel mineralizationIEA:Ensembl
Epidermis developmentIEA:Ensembl
Fatty acid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
GluconeogenesisIEA:Ensembl
Heart developmentIEA:Ensembl
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Lipid localizationIEA:Ensembl
Lipoprotein metabolic processIEA:Ensembl
Negative regulation of appetiteISS:UniProtKB
Negative regulation of blood pressureIEA:Ensembl
Negative regulation of cell growth involved in cardiac muscle cell developmentIEA:Ensembl
Negative regulation of cholesterol storageManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of cytokine production involved in inflammatory responseManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of glycolytic processManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of hepatocyte apoptotic processManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of inflammatory responseManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of leukocyte cell-cell adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of macrophage derived foam cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of miRNA transcriptionManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of neuron deathIEA:Ensembl
Negative regulation of protein bindingIEA:Ensembl
Negative regulation of protein kinase B signalingManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of reactive oxygen species biosynthetic processManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of sequestering of triglycerideManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of signaling receptor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of ATP biosynthetic processManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of fatty acid beta-oxidationManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of fatty acid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of fatty acid oxidationISS:BHF-UCL
Positive regulation of gluconeogenesisIEA:Ensembl
Positive regulation of lipid biosynthetic processManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of viral genome replicationManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of cellular ketone metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of circadian rhythmISS:UniProtKB
Regulation of fatty acid metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of fatty acid transportManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of lipid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Response to ethanolIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to insulinIEA:Ensembl
Response to lipidManual Assertion Based On ExperimentIBA:GO_Central
Wound healingIEA:Ensembl

Nucleus