PON1

The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq]

paraoxonase 1

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.

Aromatic compound catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Carboxylic acid catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Cholesterol metabolic processIEA:Ensembl
Organophosphate catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Phosphatidylcholine metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of bindingManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cholesterol effluxManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transporter activityManual Assertion Based On ExperimentIDA:BHF-UCL
Response to fatty acidIEA:Ensembl
Response to fluorideIEA:Ensembl
Response to nutrient levelsIEA:Ensembl
Response to toxic substanceManual Assertion Based On ExperimentIBA:GO_Central

Secreted, extracellular space

Microvascular complications of diabetes 5 (MVCD5):
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

Glycosylated.
The signal sequence is not cleaved.
Present in two forms, form B contains a disulfide bond, form A does not.