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Rabbit Anti-PON1 Recombinant Antibody (BA0219) (CBMAB-0678CQ)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
BA0219
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Synthetic peptide
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
paraoxonase 1
Introduction
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
Entrez Gene ID
Human5444
Mouse18979
Rat84024
UniProt ID
HumanP27169
MouseP52430
RatP55159
Alternative Names
ESA; PON; MVCD5
Function
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
Biological Process
Aromatic compound catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Carboxylic acid catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Cholesterol metabolic processIEA:Ensembl
Organophosphate catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Phosphatidylcholine metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of bindingManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cholesterol effluxManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transporter activityManual Assertion Based On ExperimentIDA:BHF-UCL
Response to fatty acidIEA:Ensembl
Response to fluorideIEA:Ensembl
Response to nutrient levelsIEA:Ensembl
Response to toxic substanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space
Involvement in disease
Microvascular complications of diabetes 5 (MVCD5):
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
PTM
Glycosylated.
The signal sequence is not cleaved.
Present in two forms, form B contains a disulfide bond, form A does not.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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