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PECAM1

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
Full Name
Platelet And Endothelial Cell Adhesion Molecule 1
Alternative Names
Platelet And Endothelial Cell Adhesion Molecule 1; CD31 Antigen; EndoCAM; PECAM-1; GPIIA; PECA1;
Function
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308).
Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684).
Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302).
Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308).
Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892).
Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892).
Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896).
Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896).
Induces susceptibility to atherosclerosis (By similarity).
Isoform Delta15
Does not protect against apoptosis.
Biological Process
Bicellular tight junction assemblyManual Assertion Based On ExperimentIMP:ARUK-UCL
Cell recognitionManual Assertion Based On ExperimentTAS:ProtInc
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell adhesionManual Assertion Based On ExperimentIDA:ARUK-UCL
Cell-cell adhesion via plasma-membrane adhesion moleculesManual Assertion Based On ExperimentIMP:UniProtKB
DiapedesisManual Assertion Based On ExperimentIDA:UniProtKB
Establishment of endothelial barrierManual Assertion Based On ExperimentIMP:ARUK-UCL
Glomerular endothelium developmentManual Assertion Based On ExperimentIEP:UniProtKB
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIMP:UniProtKB
Leukocyte cell-cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Maintenance of blood-brain barrier1 PublicationNAS:ARUK-UCL
Monocyte extravasationManual Assertion Based On ExperimentIMP:ARUK-UCL
Neutrophil extravasationManual Assertion Based On ExperimentIMP:UniProtKB
PhagocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of protein localization to cell-cell junctionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:ARUK-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation.
Isoform Long
Cell membrane
Membrane raft
Cell junction
Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Isoform Delta15
Cell junction
Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Topology
Extracellular: 28-601
Helical: 602-620
Cytoplasmic: 621-738
PTM
Phosphorylated on Ser and Tyr residues after cellular activation by src kinases (PubMed:21464369, PubMed:9298995, PubMed:19342684, PubMed:18710921).
Upon activation, phosphorylated on Ser-729 which probably initiates the dissociation of the membrane-interaction segment (residues 709-729) from the cell membrane allowing the sequential phosphorylation of Tyr-713 and Tyr-690 (PubMed:21464369).
Constitutively phosphorylated on Ser-734 in resting platelets (PubMed:21464369).
Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (By similarity).
In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation (PubMed:18710921).
Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells and enrichment in membrane rafts.

Anti-PECAM1 antibodies

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Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1404
Application*: FC
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CAP966
Application*: FC, IHC, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP965
Application*: WB
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CAP964
Application*: ELISA, FC, IHC, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 333
Application*: ELISA, IF, IHC, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: PT0034
Application*: IHC
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP963
Application*: WB
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: SZ31
Application*: IHC, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB286A
Application*: ELISA, WB, IHC, IF, FC
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB330
Application*: IF, FC
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB329
Application*: IF, FC
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB328
Application*: IF, FC
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: JC70
Application*: FC
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb138
Application*: FC, Immuno assays, IF, IP
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBHb064
Application*: FC, IHC-F, Immuno assays, IP, IHC-P, WB
Target: PECAM1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBHb010
Application*: FC, IHC-F, IF, IP, IHC-P
Target: PECAM1
Host: Mouse
Specificity: Human
Clone: IHC031
Application*: IH
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 89C2
Application*: WB, IP, P, IF (IC)
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4E3-1D9
Application*: WB, E
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Pig
Clone: 7H169
Application*: E, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 2Q854
Application*: E, F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: n.a
Application*: E, P, WB
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM247
Application*: WB, IH
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: M1081101
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: HC1/6
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: PECAM-1
Application*: WB, P
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: RM0032-1D12
Application*: P, C, IC/IF
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 13H123
Application*: F
Target: PECAM1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: MEC7.46
Application*: IP, IC/IF, C
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: SP38
Application*: IH, IC/IF, P
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: TLD-3A12
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MBC78.2
Application*: F
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: MEC 13.3
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: TP1/15
Application*: F
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-022
Application*: E, WB, IH, F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 9E6E12
Application*: E, WB, IH, IF, F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0089
Application*: F, IA, IF, IP
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYA-0044
Application*: F, C, IA, IP, P, WB
Target: PECAM1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYA-0008
Application*: F, C, IF, IP, P
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-676
Application*: E, P, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: VM64
Application*: WB, IH, FN, IF
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D260
Application*: IP, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A500
Application*: FC, IP
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1208
Application*: IH
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q681
Application*: FLISA, FC, IF, IH, IP
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13H124
Application*: FC
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1.BB.325
Application*: FC, IF, IH, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: WM59
Application*: FC
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP164
Application*: FC, P
Target: PECAM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Pig
Clone: LCI-9
Application*: C, F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-4294
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Cattle, Human
Clone: HEC7
Application*: IP, E, C, F, B, IC
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4293
Application*: E, F, FN, IP, WB
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBWJC-4290
Application*: IH, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4289
Application*: IC, F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4287
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4285
Application*: F, IF
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4284
Application*: IH, WB
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-4283
Application*: F, P, IF
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey, Rabbit, Rat
Clone: C31.3 + C31.7 + C31.10
Application*: F, IF, WB, P
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BV8
Application*: E, IP, F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4282
Application*: P
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4281
Application*: E
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBWJC-4280
Application*: P, F, FN, WB, C, IC
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4279
Application*: F, C, P, IP
Target: PECAM1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBWJC-4278
Application*: F, IH
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-2368
Application*: F, IF
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2366
Application*: F, IH, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Goat, Sheep
Clone: CO.3E-1D4
Application*: F, IH, IP, C
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2365
Application*: F, MC
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rabbit
Clone: C31.3 + JC/70A
Application*: F, IC, P, MC
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-B38
Application*: E, F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2364
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2363
Application*: WB, IP, IC
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: 78.3
Application*: E, F, IP, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 78.2
Application*: E, F, IP, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 78.1
Application*: E, F, IP, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F7B2
Application*: IC/IF, P, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: WM-59
Application*: F, IH, C
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1812
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1850
Application*: E
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-2465
Application*: F, P, IF
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RMCD31-1
Application*: IH, IF
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: C31/1395
Application*: F, P, IF
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1466
Application*: IH
Target: PECAM1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-1417
Application*: F
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: MEC13.3
Application*: F, IH, IP
Target: PECAM1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-1657
Application*: E, F, IF, IH, IP
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1694
Application*: F, IH
Target: PECAM1
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXC-1555
Application*: F
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1467
Application*: IP, WB
Target: PECAM1
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXC-1563
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-05
Application*: F
Target: PECAM1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0922
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1363
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SPM532
Application*: F, IF, P, MC
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey, Rabbit
Clone: SPM122
Application*: WB, F, IF, P
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rabbit
Clone: JC/70A
Application*: WB, IH, IF, P, C, F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CB31
Application*: F
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG, κ
Specificity: Human
Clone: C31/1395R
Application*: F, IF, P
More Infomation
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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