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PECAM1

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
Full Name
Platelet And Endothelial Cell Adhesion Molecule 1
Alternative Names
Platelet And Endothelial Cell Adhesion Molecule 1; CD31 Antigen; EndoCAM; PECAM-1; GPIIA; PECA1;
Function
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308).
Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684).
Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302).
Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308).
Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892).
Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892).
Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896).
Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896).
Induces susceptibility to atherosclerosis (By similarity).
Isoform Delta15
Does not protect against apoptosis.
Biological Process
Bicellular tight junction assemblyManual Assertion Based On ExperimentIMP:ARUK-UCL
Cell recognitionManual Assertion Based On ExperimentTAS:ProtInc
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell adhesionManual Assertion Based On ExperimentIDA:ARUK-UCL
Cell-cell adhesion via plasma-membrane adhesion moleculesManual Assertion Based On ExperimentIMP:UniProtKB
DiapedesisManual Assertion Based On ExperimentIDA:UniProtKB
Establishment of endothelial barrierManual Assertion Based On ExperimentIMP:ARUK-UCL
Glomerular endothelium developmentManual Assertion Based On ExperimentIEP:UniProtKB
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIMP:UniProtKB
Leukocyte cell-cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Maintenance of blood-brain barrier1 PublicationNAS:ARUK-UCL
Monocyte extravasationManual Assertion Based On ExperimentIMP:ARUK-UCL
Neutrophil extravasationManual Assertion Based On ExperimentIMP:UniProtKB
PhagocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of protein localization to cell-cell junctionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:ARUK-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation.
Isoform Long
Cell membrane
Membrane raft
Cell junction
Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Isoform Delta15
Cell junction
Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Topology
Extracellular: 28-601
Helical: 602-620
Cytoplasmic: 621-738
PTM
Phosphorylated on Ser and Tyr residues after cellular activation by src kinases (PubMed:21464369, PubMed:9298995, PubMed:19342684, PubMed:18710921).
Upon activation, phosphorylated on Ser-729 which probably initiates the dissociation of the membrane-interaction segment (residues 709-729) from the cell membrane allowing the sequential phosphorylation of Tyr-713 and Tyr-690 (PubMed:21464369).
Constitutively phosphorylated on Ser-734 in resting platelets (PubMed:21464369).
Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (By similarity).
In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation (PubMed:18710921).
Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells and enrichment in membrane rafts.

Anti-PECAM1 antibodies

+ Filters
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Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey, Rabbit
Clone: SPM122
Application*: WB, F, IF, P
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rabbit
Clone: JC/70A
Application*: WB, IH, IF, P, C, F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CB31
Application*: F
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG, κ
Specificity: Human
Clone: C31/1395R
Application*: F, IF, P
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: C31.12
Application*: F, IF
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: C31.10
Application*: F, P, IF
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-2429
Application*: F, IF, MC
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-3032
Application*: E
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3031
Application*: P
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-3030
Application*: C, P
Target: PECAM1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYC-3029
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: CBFYC-3028
Application*: WB, P, IF, F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig
Clone: CBFYC-0545
Application*: F
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-0544
Application*: F, IH
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0306
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Mouse, Rat
Clone: P2B1
Application*: B, IF, IH, IP
Target: PECAM1
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: 2H8
Application*: P, IF, IH, IP, WB
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: SP38
Application*: IH, IC/IF, P
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: TLD-3A12
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MBC78.2
Application*: F
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: MEC 13.3
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: TP1/15
Application*: F
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-022
Application*: E, WB, IH, F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 9E6E12
Application*: E, WB, IH, IF, F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-676
Application*: E, P, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: VM64
Application*: WB, IH, FN, IF
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D260
Application*: IP, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A500
Application*: FC, IP
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1208
Application*: IH
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q681
Application*: FLISA, FC, IF, IH, IP
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13H124
Application*: FC
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1.BB.325
Application*: FC, IF, IH, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: WM59
Application*: FC
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP164
Application*: FC, P
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: 78.3
Application*: E, F, IP, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 78.2
Application*: E, F, IP, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 78.1
Application*: E, F, IP, WB
Target: PECAM1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: MEC 7.46
Application*: F, IC, IF, C, IP
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: ER-MP12
Application*: F, IA, IP, P, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Goat, Sheep
Clone: CO-3E1D4
Application*: F, IP
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CLB-HEC/75
Application*: F, FN, IF
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey, Rabbit
Clone: C31.7
Application*: F, IF
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: C31.3
Application*: E, F, IF, P, IP, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 158-2B3
Application*: F, FN
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: 10B1371
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2725
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2724
Application*: IH, P, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYY-C2723
Application*: WB, IF, F
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C2722
Application*: E, P
Target: PECAM1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-C2721
Application*: F, IF, IH, IP
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Goat, Sheep
Clone: CBYY-C2720
Application*: F, IP
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2719
Application*: F, IH, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2717
Application*: IH, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2716
Application*: WB, P
Target: PECAM1
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-C2715
Application*: F, N
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0592
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0539
Application*: F, IH, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBYY-C0105
Application*: F, IP
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYY-C0104
Application*: E, F, IF, IH, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYY-C0062
Application*: WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 8A9
Application*: IH, P, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H107
Application*: F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 7-A1
Application*: WB, IF/C, F
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 78
Application*: E, P
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D24
Application*: F, C, WB
Target: PECAM1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 6A501
Application*: F, IF, IH, IP
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Sheep, Cattle
Clone: 6A279
Application*: F, IP
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A24
Application*: F, C, WB
Target: PECAM1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 693102
Application*: F, MC
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5E2-G4-G10
Application*: WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5A9
Application*: C, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4D1
Application*: WB, P
Target: PECAM1
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: 3H1213
Application*: F, N
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 2Q683
Application*: E, F, C, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F7
Application*: WB, E, P, C
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: 2D11
Application*: WB
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 2A14
Application*: I
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: 1H6
Application*: WB, P, IF/C, F
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D2-1A5
Application*: P
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 1D12
Application*: C, P
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13k23
Application*: WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B126
Application*: E, C, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 12
Application*: ED
Target: PECAM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Pig
Clone: 10B1361
Application*: F, IH
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 078
Application*: E, P
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 06
Application*: EC
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 009
Application*: E
Target: PECAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 007
Application*: IC/IF, IF
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 0.N.100
Application*: E, IF, IH
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 3H1221
Application*: F, IP
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 3H1217
Application*: E, F, IF, C, WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 3B5
Application*: WB
Target: PECAM1
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 390
Application*: FN, F
Target: PECAM1
Host: Rat
Antibody Isotype: IgG1
Specificity: Pig
Clone: 377537
Application*: WB, F, MC
Target: PECAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Pig
Clone: 377521
Application*: WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q690
Application*: F, IH, IP
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D3-B4-C8
Application*: WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A10
Application*: P
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 15B122
Application*: WB
Target: PECAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-A1021
Application*: E, P
More Infomation
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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