PDGFC

PDGFC is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain.

Platelet Derived Growth Factor C

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.

Activation of transmembrane receptor protein tyrosine kinase activityIEA:Ensembl
Animal organ morphogenesisIEA:Ensembl
Bone developmentIEA:Ensembl
Cellular response to amino acid stimulusIEA:Ensembl
Central nervous system developmentManual Assertion Based On ExperimentTAS:UniProtKB
Digestive tract developmentIEA:Ensembl
Embryonic organ developmentIEA:InterPro
Platelet-derived growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of fibroblast proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of MAP kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of protein autophosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl

Cytoplasm, cytosol
Secreted
Nucleus
Cytoplasmic granule
Cell membrane
Sumoylated form is predominant in the nucleus (PubMed:15247255).
Stored in alpha granules in platelets (PubMed:15061151).

Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG.
Sumoylated with SUMO1.
N-glycosylated.