PDGFA

PDGFA is a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes.

Platelet Derived Growth Factor Subunit A

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).

Actin cytoskeleton organizationISS:UniProtKB
AngiogenesisISS:UniProtKB
Animal organ morphogenesisISS:UniProtKB
Cell activationManual Assertion Based On ExperimentTAS:BHF-UCL
Cell projection assemblyISS:UniProtKB
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to transforming growth factor beta stimulusIEA:Ensembl
Embryonic lung developmentISS:BHF-UCL
Hair follicle developmentISS:UniProtKB
Inner ear developmentIEA:Ensembl
Lung alveolus developmentISS:UniProtKB
Male gonad developmentIEA:Ensembl
Negative chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of phosphatidylinositol biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of platelet activationManual Assertion Based On ExperimentIDA:BHF-UCL
Platelet-derived growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Platelet-derived growth factor receptor-alpha signaling pathway1 PublicationIC:ComplexPortal
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of fibroblast proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of MAP kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of mesenchymal cell proliferationISS:UniProtKB
Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentTAS:BHF-UCL
Regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signalingISS:UniProtKB
Regulation of peptidyl-tyrosine phosphorylationISS:UniProtKB
Regulation of smooth muscle cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Response to estradiolIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to inorganic substanceIEA:Ensembl
Response to retinoic acidIEA:Ensembl
Response to woundingManual Assertion Based On ExperimentIDA:BHF-UCL
Response to xenobiotic stimulusIEA:Ensembl
Skin developmentISS:UniProtKB
Wound healingManual Assertion Based On ExperimentTAS:BHF-UCL

Secreted
Released by platelets upon wounding.