PBRM1

This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]

Full Name

polybromo 1

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation.

Biological Process

Chromatin remodelingManual Assertion Based On ExperimentTAS:UniProtKB
Mitotic cell cycleManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cell differentiation1 PublicationIC:ComplexPortal
Positive regulation of double-strand break repair1 PublicationIC:ComplexPortal
Positive regulation of myoblast differentiation1 PublicationIC:ComplexPortal
Positive regulation of T cell differentiation1 PublicationIC:ComplexPortal
Regulation of G0 to G1 transition1 PublicationIC:ComplexPortal
Regulation of G1/S transition of mitotic cell cycle1 PublicationIC:ComplexPortal
Regulation of mitotic metaphase/anaphase transition1 PublicationIC:ComplexPortal
Regulation of nucleotide-excision repair1 PublicationIC:ComplexPortal
Regulation of transcription by RNA polymerase II1 PublicationIC:ComplexPortal

Cellular Location

Nucleus

Involvement in disease

Renal cell carcinoma (RCC):
Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype.