OSCAR

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Osteoclast Associated, Immunoglobulin-Like Receptor

Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.

Osteoclast differentiationManual Assertion Based On ExperimentIMP:MGI

Isoform 1
Secreted
Isoform 2
Cell membrane