Rat Anti-OSCAR Recombinant Antibody (CBFYA-0064) (CBMAB-X0095-FY)

Name: Rat Anti-OSCAR Recombinant Antibody (CBFYA-0064)
SKU: CBMAB-X0095-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Rat

Specificity

Mouse

Clone

CBFYA-0064

Antibody Isotype

IgG2b

Application

FC, FuncS

Basic Information

Specificity

Mouse

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% BSA

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Osteoclast Associated, Immunoglobulin-Like Receptor

Introduction

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

232790

UniProt ID

Q8VBT3

Alternative Names

Osteoclast Associated, Immunoglobulin-Like Receptor; Polymeric Immunoglobulin Receptor 3; Poly-Ig Receptor 3; PIgR-3; PIGR3; Osteoclast-Associated Immunoglobulin-Like Receptor

Function

Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.

Biological Process

Osteoclast differentiationManual Assertion Based On ExperimentIMP:MGI

Cellular Location

Isoform 1
Secreted
Isoform 2
Cell membrane

More Infomation

References

Kim, G. M., Park, H., & Lee, S. Y. (2022). Roles of osteoclast-associated receptor in rheumatoid arthritis and osteoarthritis. Joint Bone Spine, 89(5), 105400.

Ghosh, M., & Akhter, N. (2021, July). An Immunoinformation Approach of B-Cell Epitope Prediction of Osteoclast-Associated Immunoglobulin-Like Receptor. In 2021 12th International Conference on Computing Communication and Networking Technologies (ICCCNT) (pp. 1-7). IEEE.

Park, D. R., Kim, J., Kim, G. M., Lee, H., Kim, M., Hwang, D., ... & Lee, S. Y. (2020). Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation. Nature communications, 11(1), 4343.

Nedeva, I. R., Vitale, M., Elson, A., Hoyland, J. A., & Bella, J. (2021). Role of OSCAR signaling in osteoclastogenesis and bone disease. Frontiers in cell and developmental biology, 9, 641162.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Rat Anti-OSCAR Recombinant Antibody (CBXO-0496)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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