ORAI1

The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]

ORAI Calcium Release-Activated Calcium Modulator 1

Ca2+ release-activated Ca2+ (CRAC) channel subunit which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928, PubMed:20354224, PubMed:26956484).
CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901).
Plays a prominent role in Ca2+ influx at the basolateral membrane of mammary epithelial cells independently of the Ca2+ content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca2+ for milk secretion.

Adaptive immune responseIEA:UniProtKB-KW
Calcium ion importIEA:Ensembl
Calcium ion transmembrane transportManual Assertion Based On ExperimentIDA:FlyBase
Mammary gland epithelium developmentIEA:Ensembl
Positive regulation of adenylate cyclase activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of calcium ion transportManual Assertion Based On ExperimentIMP:UniProtKB
Store-operated calcium entryManual Assertion Based On ExperimentIDA:UniProtKB

Cell membrane
Basolateral cell membrane
Isoform beta is more mobile in the plasma membrane (PubMed:23307288).
Colocalizes with STIM1 at the cell membrane (PubMed:27185316).

Immunodeficiency 9 (IMD9):
An immune disorder characterized by recurrent infections, impaired activation and proliferative response of T-cells, decreased T-cell production of cytokines, and normal lymphocytes counts and serum immunoglobulin levels. In surviving patients ectodermal dysplasia with anhidrosis and non-progressive myopathy may be observed.
Myopathy, tubular aggregate, 2 (TAM2):
A rare congenital myopathy characterized by regular arrays of membrane tubules on muscle biopsies without additional histopathological hallmarks. Tubular aggregates in muscle are structures of variable appearance consisting of an outer tubule containing either one or more microtubule-like structures or amorphous material. TAM2 patients have myopathy and pupillary abnormalities.

Cytoplasmic: 1-87
Helical: 88-105
Extracellular: 106-119
Helical: 120-140
Cytoplasmic: 141-173
Helical: 174-194
Extracellular: 195-234
Helical: 235-255
Cytoplasmic: 256-301

N-glycosylated (PubMed:19249086, PubMed:26956484).
N-glycosylation inhibits channel activity in T cells (PubMed:26956484).
Ubiquitinated.
Cys-195 is oxidated, leading to inactivation of channel activity.