NUDT9

The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Nudix Hydrolase 9

Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.

ADP catabolic processIEA:Ensembl
IDP catabolic processIEA:Ensembl
Nucleobase-containing small molecule metabolic processTAS:Reactome

Isoform 1
Mitochondrion