NSF

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).

N-Ethylmaleimide Sensitive Factor, Vesicle Fusing ATPase

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).

ExocytosisManual Assertion Based On ExperimentTAS:UniProtKB
Golgi to plasma membrane protein transportManual Assertion Based On ExperimentIBA:GO_Central
Intra-Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Intracellular protein transportManual Assertion Based On ExperimentIMP:CACAO
Plasma membrane fusionManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of protein catabolic processManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of receptor recyclingManual Assertion Based On ExperimentIDA:UniProtKB
Potassium ion transportIEA:Ensembl
Regulation of exocytosisISS:ParkinsonsUK-UCL
SNARE complex disassemblyISS:ParkinsonsUK-UCL
Vesicle-mediated transportISS:ParkinsonsUK-UCL

Cytoplasm

Developmental and epileptic encephalopathy 96 (DEE96):
A form of epileptic encephalopathy, a heterogeneous group of early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE96 is an autosomal dominant form characterized by onset of seizures in the first days or weeks of life. Affected infants also have hypotonia with respiratory insufficiency that may result in premature death.

Phosphorylation at Ser-569 interferes with homohexamerization.