NPM3

The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq]

nucleophosmin/nucleoplasmin, 3

Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning (PubMed:22362753, PubMed:20073534).
Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM (PubMed:22362753).
Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM (PubMed:15596447).

Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
rRNA processingIEA:Ensembl
rRNA transcriptionIEA:Ensembl

Nucleus
Nucleus, nucleolus
Mainly found in the granular component of the nucleolus.

Phosphorylated.