Mouse Anti-NPM3 Recombinant Antibody (3F2) (CBMAB-N3163-WJ)

Name: Mouse Anti-NPM3 Recombinant Antibody (3F2)
SKU: CBMAB-N3163-WJ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

3F2

Antibody Isotype

IgG2a, κ

Application

ELISA, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

nucleophosmin/nucleoplasmin, 3

Introduction

The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008]

Entrez Gene ID

10360

UniProt ID

O75607

Alternative Names

Nucleophosmin/Nucleoplasmin 3; Nucleophosmin/Nucleoplasmin Family, Member 3; Nucleoplasmin-3; TMEM123; PORMIN;

Function

Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning (PubMed:22362753, PubMed:20073534).
Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM (PubMed:22362753).
Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM (PubMed:15596447).

Biological Process

Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
rRNA processingIEA:Ensembl
rRNA transcriptionIEA:Ensembl

Cellular Location

Nucleus
Nucleus, nucleolus
Mainly found in the granular component of the nucleolus.

PTM

Phosphorylated.

More Infomation

References

Wang, H., Zhou, Z., Zhang, J., Hao, T., Wang, P., Wu, P., ... & Yin, S. (2024). Pumilio1 regulates NPM3/NPM1 axis to promote PD-L1-mediated immune escape in gastric cancer. Cancer Letters, 581, 216498.

Wei, Q., Zhou, J., Wang, X., Li, Z., Chen, X., Chen, K., & Jiang, R. (2023). Pan-cancer analysis of the prognostic and immunological role of nucleophosmin/nucleoplasmin 3 (NPM3) and its potential significance in lung adenocarcinoma. Cancer Pathogenesis and Therapy, 1(04), 238-252.

López, D. J., Rodríguez, J. A., & Bañuelos, S. (2020). Nucleophosmin, a multifunctional nucleolar organizer with a role in DNA repair. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1868(12), 140532.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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