NME2

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product.

NME2

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197).
Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752, PubMed:19435876).
Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III1 region of the MYC gene promoter. Does not bind to duplex NHE III1 (PubMed:19435876).
Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041).
Exhibits histidine protein kinase activity (PubMed:20946858).

Cell adhesionManual Assertion Based On ExperimentTAS:HGNC-UCL
CTP biosynthetic processIEA:InterPro
GTP biosynthetic processIEA:InterPro
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:HGNC-UCL
Nucleoside diphosphate phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Nucleoside triphosphate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of epithelial cell proliferationManual Assertion Based On ExperimentIMP:HGNC-UCL
Positive regulation of keratinocyte differentiationManual Assertion Based On ExperimentIMP:HGNC-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of epidermis developmentManual Assertion Based On ExperimentIMP:HGNC-UCL
UTP biosynthetic processIEA:InterPro

Cytoplasm
Cell projection, lamellipodium
Cell projection, ruffle
Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates.
Isoform 1
Cytoplasm
Cytoplasm, perinuclear region
Nucleus
Isoform 3
Cytoplasm
Cytoplasm, perinuclear region
Nucleus