NKX3-1

This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]

Full Name

NK3 Homeobox 1

Function

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.

Biological Process

Activation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Androgen receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Branching involved in prostate gland morphogenesisISS:UniProtKB
Branching morphogenesis of an epithelial tubeISS:UniProtKB
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to hypoxiaManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to interleukin-1Manual Assertion Based On ExperimentIEP:UniProtKB
Cellular response to steroid hormone stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to tumor necrosis factorManual Assertion Based On ExperimentIEP:UniProtKB
Cellular response to xenobiotic stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Dorsal aorta developmentIEA:Ensembl
Epithelial cell proliferation involved in salivary gland morphogenesisISS:UniProtKB
Heart developmentIEA:Ensembl
Male gonad developmentIEA:Ensembl
Metanephros developmentIEA:Ensembl
Negative regulation of cell cycle G1/S phase transitionManual Assertion Based On ExperimentIGI:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of epithelial cell proliferationISS:UniProtKB
Negative regulation of epithelial cell proliferation involved in prostate gland developmentISS:UniProtKB
Negative regulation of gene expressionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of insulin-like growth factor receptor signaling pathwayISS:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Pharyngeal system developmentIEA:Ensembl
Positive regulation of androgen secretionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell deathManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell divisionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of DNA-binding transcription factor activityIEA:Ensembl
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of mitotic cell cycleManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Protein kinase B signalingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templated1 PublicationNAS:UniProtKB
Response to testosteroneISS:UniProtKB
Salivary gland developmentISS:UniProtKB
SomitogenesisIEA:Ensembl

Cellular Location

Nucleus

PTM

Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.

Anti-NKX3-1 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)