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NEFM

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Full Name
Neurofilament Medium
Function
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity).
Biological Process
Neurofilament bundle assembly Source: BHF-UCL
Cellular Location
Cytoskeleton
Other locations
axon
PTM
There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function.
Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.

Anti-NEFM antibodies

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Mouse Anti-NEFM Recombinant Antibody (A1318) (CBMAB-AP12547LY)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: A1318
Application*: ELISA, IHC, WB

Mouse Anti-NEFM Recombinant Antibody (CBMAB-BR369LY)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat, Cattle, Chicken, Horse, Human, Mouse, Pig
Application*: IF, IHC, WB

Mouse anti-ITGA7 Recombinant Antibody (2E30) (CBMAB-1317-LY)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2E30
Application*: WB, C

Mouse Anti-NEFM Recombinant Antibody (RNF406) (CBMAB-1282-LY)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: RNF406
Application*: C, P, WB

Mouse Anti-NEFM Recombinant Antibody (RMO44) (CBMAB-1281-LY)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Zebrafish, Leptospirosis
Clone: RMO44
Application*: WB, E, P, C, IC/IF, IH

Mouse Anti-NEFM Recombinant Antibody (NF403) (CBMAB-1280-LY)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: NF403
Application*: IH, WB

Mouse Anti-NEFM Recombinant Antibody (NF-09) (CBMAB-1279-LY)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Cattle, Cat, Pig
Clone: NF-09
Application*: WB, E, P, C, IC/IF, IH

Rabbit Anti-NEFM Recombinant Antibody (EP2460) (CBMAB-1276-LY)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EP2460
Application*: WB, IP, P, IC/IF

Mouse Anti-NEFM Recombinant Antibody (3H11) (CBMAB-1275-LY)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 3H11
Application*: WB, C, P, IC/IF

Mouse Anti-NEFM Recombinant Antibody (2H3) (CBMAB-0139-CN)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human, Mouse
Clone: 2H3
Application*: IF, IH, WB

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0866) (CBMAB-N1899-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Specificity: Frog, Guinea pig, Hamster, Human, Monkey, Rabbit
Clone: CBWJN-0866
Application*: WB, IH, F

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0857) (CBMAB-N1898-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0857
Application*: C, WB

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0799) (CBMAB-N1896-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Leech, Rat
Clone: CBWJN-0799
Application*: IC, IF, IH, IP, WB

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0798) (CBMAB-N1895-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBWJN-0798
Application*: IF, IH, IP, WB

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0796) (CBMAB-N1894-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBWJN-0796
Application*: E, IF, IH, WB

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0739) (CBMAB-N1893-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Rat
Clone: CBWJN-0739
Application*: C, P, WB

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0703) (CBMAB-N1892-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: CBWJN-0703
Application*: IH

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0651) (CBMAB-N1891-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBWJN-0651
Application*: WB

Mouse Anti-NEFM Recombinant Antibody (LB-961) (CBMAB-N1890-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Rat, Hamster, Cattle, Human, Monkey
Clone: LB-961
Application*: WB, C, IC

Rabbit Anti-NEFM Recombinant Antibody (CBWJN-1311) (CBMAB-N1889-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-1311
Application*: WB, IH, IP

Rabbit Anti-NEFM Recombinant Antibody (CBWJN-0836) (CBMAB-N1888-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJN-0836
Application*: WB, F, IP

Rabbit Anti-NEFM Recombinant Antibody (CBWJN-0828) (CBMAB-N1887-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-0828
Application*: IC, IH, IP, WB

Mouse Anti-NEFM Recombinant Antibody (E-9) (CBMAB-N1886-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: E-9
Application*: WB, IP, IF, E

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0489) (CBMAB-N1885-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG
Specificity: Chicken, Human, Mouse, Rat
Clone: CBWJN-0489
Application*: IC, IH, WB

Mouse Anti-NEFM Recombinant Antibody (6H9) (CBMAB-N1884-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 6H9
Application*: IF, WB

Mouse Anti-NEFM Recombinant Antibody (5H52) (CBMAB-N1883-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Human, Rat
Clone: 5H52
Application*: WB, IC, F

Mouse Anti-NEFM Recombinant Antibody (5H4) (CBMAB-N1882-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5H4
Application*: WB

Mouse Anti-NEFM Recombinant Antibody (5B7) (CBMAB-N1880-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5B7
Application*: WB, IH

Mouse Anti-NEFM Recombinant Antibody (4H360) (CBMAB-N1879-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Specificity: Human, Rat
Clone: 4H360
Application*: IH, WB

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0374) (CBMAB-N1877-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cattle, Hamster, Human, Mouse, Rabbit, Rat
Clone: CBWJN-0374
Application*: E, IH, IP, WB

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0373) (CBMAB-N1876-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: CBWJN-0373
Application*: E, F, IH, IP, WB

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0371) (CBMAB-N1875-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: CBWJN-0371
Application*: E, IH, IP

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0370) (CBMAB-N1874-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Human, Mouse, Pig, Rat
Clone: CBWJN-0370
Application*: E, IF, IH, WB

Mouse Anti-NEFM Recombinant Antibody (3C163) (CBMAB-N1873-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Avian, Human, Pig
Clone: 3C163
Application*: E, WB

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0012) (CBMAB-N1872-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG
Specificity: Avian, Rat
Clone: CBWJN-0012
Application*: WB, IH

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0009) (CBMAB-N1871-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Chicken, Rat
Clone: CBWJN-0009
Application*: E, F, IC, IF, IH, WB

Mouse Anti-NEFM Recombinant Antibody (2G3) (CBMAB-N1870-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G3
Application*: WB, IH

Mouse Anti-NEFM Recombinant Antibody (2G12) (CBMAB-N1869-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G12
Application*: WB, F, E, MC

Mouse Anti-NEFM Recombinant Antibody (2E3B12) (CBMAB-N1868-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 2E3B12
Application*: E, IH, WB

Mouse Anti-NEFM Recombinant Antibody (1A4) (CBMAB-N1866-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A4
Application*: WB, IF

Mouse Anti-NEFM Recombinant Antibody (1A3C7) (CBMAB-N1865-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Pig
Clone: 1A3C7
Application*: E, IF, IH, WB

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0169) (CBMAB-N1864-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBWJN-0169
Application*: IF, IH, WB

Mouse Anti-NEFM Recombinant Antibody (4E162) (CBMAB-N1863-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Human, Mouse, Rat
Clone: 4E162
Application*: WB, IC

Mouse Anti-NEFM Recombinant Antibody (CBWJN-1310) (CBMAB-N1862-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1310
Application*: WB

Mouse Anti-NEFM Recombinant Antibody (CBWJN-1309) (CBMAB-N1861-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBWJN-1309
Application*: WB, IH

Mouse Anti-NEFM Recombinant Antibody (CBWJN-1308) (CBMAB-N1860-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBWJN-1308
Application*: WB, IH

Mouse Anti-NEFM Recombinant Antibody (CBWJN-1307) (CBMAB-N1859-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBWJN-1307
Application*: WB, IH, P

Mouse Anti-NEFM Recombinant Antibody (CBWJN-1306) (CBMAB-N1858-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBWJN-1306
Application*: WB, IH, IF

Mouse Anti-NEFM Recombinant Antibody (CBWJN-1305) (CBMAB-N1857-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1305
Application*: C, P

Mouse Anti-NEFM Recombinant Antibody (CBWJN-1304) (CBMAB-N1856-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJN-1304
Application*: P, C

Mouse Anti-NEFM Recombinant Antibody (CBWJN-0860) (CBMAB-N0238-WJ)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Hamster, Frog
Clone: CBWJN-0860
Application*: WB, IH, P, C

Mouse Anti-NEFM Recombinant Antibody (4H6) (CBMAB-0229-CN)

Datasheet Datasheet SDS SDS
Target: NEFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Avian
Clone: 4H6
Application*: IF, IH, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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