NAE1

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

NEDD8 activating enzyme E1 subunit 1

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.

Mitotic DNA replication checkpoint signaling Source: UniProtKB
Neuron apoptotic process Source: UniProtKB
Protein modification by small protein conjugation Source: GO_Central
Protein neddylation Source: UniProtKB
Regulation of apoptotic process Source: UniProtKB
Regulation of neuron apoptotic process Source: UniProtKB
Signal transduction Source: ProtInc

Cell membrane
Note: Colocalizes with APP in lipid rafts.

Ubiquitinated by TRIP12, leading to its degradation by the proteasome.