Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-NAE1 Recombinant Antibody (CBWJN-0341) (CBMAB-N1070-WJ)


See all NAE1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-0341
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NEDD8 activating enzyme E1 subunit 1
Introduction
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
8883
UniProt ID
Q13564
Alternative Names
NEDD8 Activating Enzyme E1 Subunit 1; Amyloid Beta Precursor Protein-Binding Protein 1, 59 KDa; Amyloid Beta Precursor Protein Binding Protein 1, 59kDa; Amyloid Protein-Binding Protein 1; Proto-Oncogene Protein 1; APP-BP1; APPBP1; Amyloid Beta Precursor Protein-Binding Protein 1, 59kD;
Function
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Biological Process
Mitotic DNA replication checkpoint signaling Source: UniProtKB
Neuron apoptotic process Source: UniProtKB
Protein modification by small protein conjugation Source: GO_Central
Protein neddylation Source: UniProtKB
Regulation of apoptotic process Source: UniProtKB
Regulation of neuron apoptotic process Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Cell membrane
Note: Colocalizes with APP in lipid rafts.
PTM
Ubiquitinated by TRIP12, leading to its degradation by the proteasome.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-NAE1 Recombinant Antibody (CBWJN-0341)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry