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MUC16

This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]
Full Name
Mucin 16, Cell Surface Associated
Function
Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Biological Process
Cell adhesion Source: UniProtKB
Cellular Location
Extracellular space
Plasma membrane
Cell membrane
Note: May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
Topology
Extracellular: 1-14451
Helical: 14452-14472
Cytoplasmic: 14473-14507
PTM
Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.
Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.
May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.
May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.

Anti-MUC16 antibodies

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Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1225
Application*: ELISA, IHC
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CB040
Application*: IVD
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CB039
Application*: IVD
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0504
Application*: SE
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0503
Application*: SE
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0502
Application*: SE
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0501
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0500
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0499
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYR0498
Target: MUC16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYR0497
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYR0496
Target: MUC16
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYR0443
Application*: FC
Target: MUC16
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYR0442
Application*: FC
Target: MUC16
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYR0441
Application*: FC
Target: MUC16
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYR0440
Application*: E
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0439
Application*: E
Target: MUC16
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: IHC125
Application*: P, E, IH
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: OV185-1
Application*: IC, IF, P
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: X75
Application*: E, P, WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: X325
Application*: E, P, WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9A101
Application*: E
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8J453
Application*: E, WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3G33
Application*: IH
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1.B.827
Application*: E, WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-4217
Application*: IC, IF, P
Target: MUC16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-4214
Application*: E, IH
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4209
Application*: E
Target: MUC16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-2339
Application*: E, IH, WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: MOC-52
Application*: C, IF
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: X306
Application*: WB, E, M, SE
Target: MUC16
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-0679
Application*: P
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0678
Application*: P
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: OC125
Application*: C, P
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0677
Application*: E, P
Target: MUC16
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2681
Application*: E
Target: MUC16
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C2680
Application*: IH, E
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2679
Application*: WB, P, F
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2678
Application*: E, IH
Target: MUC16
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C2677
Application*: WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2985
Application*: E, IH, WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBFYC-2984
Application*: E, WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2983
Application*: IH, E
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-2982
Application*: IC, IF, IH
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2981
Application*: F, SE
Target: MUC16
Host: Mouse
Specificity: Human
Clone: CBFYC-0240
Application*: E, F, IH
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: 13F5
Application*: E, WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2797
Application*: E, IH, WB
Target: MUC16
Host: Mouse
Specificity: Human
Clone: CBFYM-2796
Application*: WB, IC, P, C, E
Target: MUC16
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2795
Application*: WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2794
Application*: P, WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-2793
Application*: WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0744
Application*: IH
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0743
Application*: E, WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0348
Application*: E, IH, WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1.B.830
Application*: E, C, WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 76
Application*: IH, E
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 618F
Application*: WB, P, F
Target: MUC16
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3C6
Application*: WB
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F1
Application*: E
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C4
Application*: WB, IH
Target: MUC16
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 15
Application*: IH, E
Target: MUC16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 0.N.37
Application*: IH
Target: MUC16
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CF294
Application*: ELISA, IHC
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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