MNDA

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]

Myeloid Cell Nuclear Differentiation Antigen

May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.

Activation of innate immune response Source: GO_Central
B cell receptor signaling pathway Source: UniProtKB
Cellular defense response Source: ProtInc
Cellular response to DNA damage stimulus Source: UniProtKB
Cellular response to interferon-beta Source: GO_Central
Negative regulation of B cell proliferation Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of interleukin-1 beta production Source: GO_Central

Nucleus
Cytoplasm
Note: Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.