MMP1
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Full Name
Matrix Metallopeptidase 1
Function
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:2557822, PubMed:2153297, PubMed:1645757).
In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369).
In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369).
Biological Process
Cellular protein metabolic process Source: Reactome
Cellular response to UV-A Source: UniProtKB
Collagen catabolic process Source: GO_Central
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Positive regulation of protein-containing complex assembly Source: ParkinsonsUK-UCL
Proteolysis Source: ParkinsonsUK-UCL
Cellular response to UV-A Source: UniProtKB
Collagen catabolic process Source: GO_Central
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Positive regulation of protein-containing complex assembly Source: ParkinsonsUK-UCL
Proteolysis Source: ParkinsonsUK-UCL
Cellular Location
Extracellular matrix
PTM
Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.
Tyrosine phosphorylated in platelets by PKDCC/VLK.
Tyrosine phosphorylated in platelets by PKDCC/VLK.
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Anti-MMP1 antibodies
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CompareTarget: MMP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Common fruit fly
Clone: 3A6B4
Application*: IF, IP, WB
Target: MMP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Common fruit fly
Clone: 14A3D2
Application*: E
Target: MMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1136
Application*: IHC, WB
Target: MMP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E9S9N
Application*: WB, IP
Target: MMP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E11
Application*: E, E
Target: MMP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5C10
Application*: WB
Target: MMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B6
Application*: IH, IF, IP, WB
Target: MMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2343
Application*: E, WB
Target: MMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2342
Application*: IH, WB
Target: MMP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2341
Application*: E, C, P, WB
Target: MMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2340
Application*: WB
Target: MMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2338
Application*: F
Target: MMP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-2337
Application*: F, IC, IH, IP, WB
Target: MMP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2336
Application*: E, IH, WB
Target: MMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2335
Application*: E, F, IH, WB
Target: MMP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-0663
Application*: WB
Target: MMP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-0662
Application*: E, IH, WB
Target: MMP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-0661
Application*: E
Target: MMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0660
Application*: IH, WB
Target: MMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0193
Application*: E, IF, P, WB
Target: MMP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: SB12e
Application*: E, IH, P
Target: MMP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT889
Application*: WB, P, IF, IC, F, E
Target: MMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3825
Application*: IH, IC, F
Target: MMP1
Specificity: Human
Target: MMP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Common fruit fly
Clone: 3B8D12
Application*: IF, IH, IP, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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