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MAPK7

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Full Name
Mitogen-Activated Protein Kinase 7
Function
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
Biological Process
cAMP-mediated signaling1 PublicationNAS:BHF-UCL
Cell cycleIEA:UniProtKB-KW
Cell differentiationIEA:UniProtKB-KW
Cellular response to growth factor stimulusManual Assertion Based On ExperimentIGI:BHF-UCL
Cellular response to hydrogen peroxideManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to laminar fluid shear stressManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to transforming growth factor beta stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of calcineurin-NFAT signaling cascadeIEA:Ensembl
Negative regulation of cyclic-nucleotide phosphodiesterase activity1 PublicationNAS:BHF-UCL
Negative regulation of endothelial cell apoptotic processManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandManual Assertion Based On ExperimentIGI:BHF-UCL
Negative regulation of heterotypic cell-cell adhesionManual Assertion Based On ExperimentIGI:BHF-UCL
Negative regulation of inflammatory responseManual Assertion Based On ExperimentTAS:BHF-UCL
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of response to cytokine stimulusManual Assertion Based On ExperimentIGI:BHF-UCL
Peptidyl-serine phosphorylationIEA:Ensembl
Positive regulation of protein metabolic processManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of transcription from RNA polymerase II promoter in response to stressManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of angiogenesisIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
Nucleus, PML body
Translocates to the nucleus upon activation.
PTM
Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity).
Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.

Anti-MAPK7 antibodies

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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
Target: MAPK7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D23E9
Application*: WB
Target: MAPK7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Horse
Clone: D3I5V
Application*: WB, IP
Target: MAPK7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human, Mouse, Rat
Clone: CBFYM-1635
Application*: WB
Target: MAPK7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: EG1140
Application*: WB
Target: MAPK7
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: OTI3D4
Application*: WB
Target: MAPK7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBFYE-1542
Application*: WB
Target: MAPK7
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey, Horse
Clone: CBFYE-1543
Application*: WB, IP
Target: MAPK7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1544
Application*: WB, F, IF
Target: MAPK7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EP791Y
Application*: IC, F, IP, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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