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MAP2

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.

Full Name

Microtubule Associated Protein 2

Alternative Names

Microtubule Associated Protein 2; MAP-2; Microtubule-Associated Protein 2; MAP2A; MAP2B; MAP2C;

Function

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

Biological Process

Central nervous system neuron developmentManual Assertion Based On ExperimentIEP:DFLAT
Dendrite developmentManual Assertion Based On ExperimentTAS:ARUK-UCL
Dendrite morphogenesisManual Assertion Based On ExperimentIEP:DFLAT
Microtubule bundle formationIEA:InterPro
Microtubule cytoskeleton organizationISS:ARUK-UCL
Negative regulation of axon extensionISS:ARUK-UCL
Negative regulation of microtubule bindingISS:ARUK-UCL
Negative regulation of microtubule polymerizationISS:ARUK-UCL
Neuron projection developmentManual Assertion Based On ExperimentIEP:DFLAT
Positive regulation of anterograde dense core granule transportISS:ARUK-UCL
Positive regulation of anterograde synaptic vesicle transportISS:ARUK-UCL
Regulation of microtubule polymerizationManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of organelle transport along microtubuleISS:ARUK-UCL
Regulation of protein localizationISS:ARUK-UCL

Cellular Location

Cytoplasm, cytoskeleton
Cell projection, dendrite

PTM

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity).
Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).

Anti-MAP2 antibodies

Mouse Anti-MAP2 Recombinant Antibody (CBFYM-1410) (CBMAB-M1570-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBFYM-1410

Application*: IF, C, P, IP, WB

Mouse Anti-MAP2 Recombinant Antibody (CBFYM-1395) (CBMAB-M1555-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Human, Mouse, Pig

Clone: CBFYM-1395

Application*: E, IC, C, P, IP, WB

Rabbit Anti-MAP2 Recombinant Antibody (CBFYM-1409) (CBMAB-M1569-FY)

SDS

Target: MAP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBFYM-1409

Application*: WB, IP, IF

Mouse Anti-MAP2 (AA 997-1332) Recombinant Antibody (CBFYM-1394) (CBMAB-M1554-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle

Clone: CBFYM-1394

Application*: P, WB

Rabbit Anti-MAP2 Recombinant Antibody (CBFYM-1408) (CBMAB-M1568-FY)

SDS

Target: MAP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBFYM-1408

Application*: P

Mouse Anti-MAP2 (AA 1375-1395) Recombinant Antibody (CBFYM-1407) (CBMAB-M1567-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Pig, Mouse

Clone: CBFYM-1407

Application*: IC, P, C, E, IP, WB

Mouse Anti-MAP2 Recombinant Antibody (CBFYM-1406) (CBMAB-M1566-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBFYM-1406

Application*: E, F, IC, IF, IH, IP, WB

Mouse Anti-MAP2 Recombinant Antibody (CBFYM-1405) (CBMAB-M1565-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rabbit, Rat

Clone: CBFYM-1405

Application*: IH, P, WB

Mouse Anti-MAP2 (N-terminus) Recombinant Antibody (CBFYM-1403) (CBMAB-M1563-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: CBFYM-1403

Application*: IC, IP, WB

Mouse Anti-MAP2 (AA 24-123) Recombinant Antibody (CBFYM-1401) (CBMAB-M1561-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-1401

Application*: E, F, WB

Mouse Anti-MAP2 (AA 1689-1824) Recombinant Antibody (CBFYM-1399) (CBMAB-M1559-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human

Clone: CBFYM-1399

Application*: IH, IC

Mouse Anti-MAP2 (C-terminus) Recombinant Antibody (CBFYM-1398) (CBMAB-M1558-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYM-1398

Application*: E, WB

Mouse Anti-MAP2 (AA 2-110) Recombinant Antibody (CBFYM-1397) (CBMAB-M1557-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYM-1397

Application*: WB, IP, IC

Mouse Anti-MAP2 Recombinant Antibody (CBFYM-1396) (CBMAB-M1556-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Human, Mouse, Rat

Clone: CBFYM-1396

Application*: WB, IF, IH

Mouse Anti-MAP2 Recombinant Antibody (1D7-B9-C8-F6) (CBMAB-Z0376-LY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: 1D7-B9-C8-F6

Application*: WB, IP, IC

Mouse Anti-MAP2 Recombinant Antibody (MP-2) (CBMAB-AO713LY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: MP-2

Application*: ELISA, WB, IHC

Mouse Anti-MAP2 Recombinant Antibody (CB379A) (CBMAB-CA379LY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CB379A

Application*: ELISA, IHC

Mouse Anti-MAP2 Recombinant Antibody (CB416A) (CBMAB-CA416LY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Cattle, Mouse, Rat, Pig

Clone: CB416A

Application*: ELISA, WB, ICC

Mouse Anti-MAP2 Recombinant Antibody (A986) (CBMAB-AP11661LY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: A986

Application*: IF, IHC

Mouse Anti-MAP2 Recombinant Antibody (A987) (CBMAB-AP4382LY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: A987

Application*: IHC, WB

Mouse Anti-MAP2 Recombinant Antibody (A988) (CBMAB-AP4378LY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: A988

Application*: ELISA, IHC

Mouse Anti-MAP2 Recombinant Antibody (A989) (CBMAB-AP4379LY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Cattle, Human, Mouse, Pig, Rat

Clone: A989

Application*: ELISA, ICC, WB

Mouse Anti-MAP2 Recombinant Antibody (A990) (CBMAB-AP4383LY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: A990

Application*: IHC

Mouse Anti-MAP2 Recombinant Antibody (A991) (CBMAB-AP11663LY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: A991

Application*: ICC, IP, WB

Mouse Anti-MAP2 Recombinant Antibody (A992) (CBMAB-AP4384LY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Cattle, Human, Mouse, Pig, Rat

Clone: A992

Application*: ICC, WB

Mouse Anti-MAP2 Recombinant Antibody (EC188) (V2LY-0624-LY188)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EC188

Application*: P, IF

Mouse Anti-MAP2 Monoclonal Antibody (AP20) (CBMAB-1385-YC)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Rat, Human

Clone: AP20

Application*: IF, IC, P, WB

Mouse Anti-MAP2 Recombinant Antibody (CBFYM-0551) (CBMAB-M0680-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBFYM-0551

Application*: IH, WB

Mouse Anti-MAP2 Recombinant Antibody (CBFYM-0550) (CBMAB-M0679-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Mouse

Clone: CBFYM-0550

Application*: E, WB

Mouse Anti-MAP2 Recombinant Antibody (CBFYM-0061) (CBMAB-M0069-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-0061

Application*: WB, P, IF

Mouse Anti-MAP2 Recombinant Antibody (CBFYM-0169) (CBMAB-M0192-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Cattle

Clone: CBFYM-0169

Application*: WB, IH, IF

Mouse Anti-MAP2 Recombinant Antibody (CBFYM-0180) (CBMAB-M0209-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Cattle

Clone: CBFYM-0180

Application*: IC, IF, WB

Mouse Anti-MAP2 Recombinant Antibody (CBFYM-0239) (CBMAB-M0299-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Chicken, Human, Mouse, Quail, Rat, Frog

Clone: CBFYM-0239

Application*: C, IF, WB, P

Mouse Anti-MAP2 Recombinant Antibody (CBFYM-0325) (CBMAB-M0392-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Chicken, Cattle, Human, Quail

Clone: CBFYM-0325

Application*: WB, IP, P, C, IC, IF

Mouse Anti-MAP2 Recombinant Antibody (CBFYM-0374) (CBMAB-M0463-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Cat, Mouse, Pig, Rat

Clone: CBFYM-0374

Application*: IC, IF, IP, WB

Mouse Anti-MAP2 Recombinant Antibody (CBFYM-0548) (CBMAB-M0677-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle

Clone: CBFYM-0548

Application*: IF, IH, IP, WB

Mouse Anti-MAP2 Recombinant Antibody (CBFYM-0549) (CBMAB-M0678-FY)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-0549

Application*: IH, WB

Mouse Anti-MAP2 Monoclonal Antibody (AP18) (CBMAB-1384-YC)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Cattle, Avian, Human, Mouse, Rat, Frog, Guinea pig

Clone: AP18

Application*: IF, IC, P, WB

Mouse Anti-MAP2 Monoclonal Antibody (HM-2) (CBMAB-1386-YC)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Chicken, Cattle, Human, Quail

Clone: HM-2

Application*: IC, IF, C, P, WB

Mouse Anti-MAP2 Monoclonal Antibody (MT-01) (CBMAB-1387-YC)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Cattle, Cat, Pig

Clone: MT-01

Application*: IC, IP, IF, WB

Mouse Anti-MAP2 Monoclonal Antibody (AP-20) (CBMAB-1388-YC)

SDS

Target: MAP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Mouse, Rat, Frog, Zebrafish, Quail, Salamander

Clone: AP-20

Application*: IC, IF, C, P, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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