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MAGEA1

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

Full Name

MAGE Family Member A1

Function

May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Biological Process

Negative regulation of Notch signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Nucleus

Anti-MAGEA1 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-MAGEA1 Recombinant Antibody (A976) (CBMAB-AP4368LY)

SDS

Target: MAGEA1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Dog, Human

Clone: A976

Application*: FC, IF, IHC

Mouse Anti-MAGEA1 Recombinant Antibody (A975) (CBMAB-AP4370LY)

SDS

Target: MAGEA1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: A975

Application*: FC, IF, IHC

Mouse Anti-MAGEA1 Recombinant Antibody (A974) (CBMAB-AP4366LY)

SDS

Target: MAGEA1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Dog, Human

Clone: A974

Application*: FC, IF, IHC

Mouse Anti-MAGEA1 Recombinant Antibody (3H5) (CBMAB-A5154-LY)

SDS

Target: MAGEA1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3H5

Application*: WB, E

Recombinant Mouse Anti-MAGEA1 Recombinant Antibody (MA454) (CBMAB-XB0773-YC)

SDS

Target: MAGEA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: MA454

Application*: IH, WB

Recombinant Mouse Anti-MAGEA1 Recombinant Antibody (6C-1) (CBMAB-XB0772-YC)

SDS

Target: MAGEA1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 6C-1

Application*: WB

Rabbit Anti-MAGEA1 Recombinant Antibody (CBFYM-1301) (CBMAB-M1460-FY)

SDS

Target: MAGEA1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBFYM-1301

Application*: WB, IC, F

Mouse Anti-MAGEA1 Recombinant Antibody (CBFYM-1299) (CBMAB-M1458-FY)

SDS

Target: MAGEA1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-1299

Application*: P, IF, F

Mouse Anti-MAGEA1 Recombinant Antibody (CBFYM-1298) (CBMAB-M1457-FY)

SDS

Target: MAGEA1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-1298

Application*: E, IF, IH, IP, WB

Mouse Anti-MAGEA1 (AA 98-171) Recombinant Antibody (CBFYM-1297) (CBMAB-M1456-FY)

SDS

Target: MAGEA1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-1297

Application*: E, WB

Rabbit Anti-MAGEA1 Recombinant Antibody (CBFYM-1295) (CBMAB-M1454-FY)

SDS

Target: MAGEA1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYM-1295

Application*: WB, P, F

Mouse Anti-MAGEA1 Recombinant Antibody (CBFYM-0621) (CBMAB-M0755-FY)

SDS

Target: MAGEA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-0621

Application*: IH

Mouse Anti-MAGEA1 Recombinant Antibody (CBFYM-0536) (CBMAB-M0665-FY)

SDS

Target: MAGEA1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-0536

Application*: E, IC, IF, C, IP, WB

Mouse Anti-MAGEA1 Recombinant Antibody (CBFYM-0423) (CBMAB-M0537-FY)

SDS

Target: MAGEA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Dog, Human, Rat

Clone: CBFYM-0423

Application*: C, F, IF, IP, P, WB

Mouse Anti-MAGEA1 Recombinant Antibody (CBFYM-0350) (CBMAB-M0427-FY)

SDS

Target: MAGEA1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-0350

Application*: IF, P, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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