Search : Keywords Target

loading...

Welcome Sign in or Don't have an account?Register

LYVE1

Lymphatic vessel endothelial hyaluronan receptor 1 is a Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. It plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). It may act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Full Name

Lymphatic Vessel Endothelial Hyaluronan Receptor 1

Function

Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10037799).
Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (PubMed:26823460).

Biological Process

Anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cell-matrix adhesionManual Assertion Based On ExperimentTAS:ProtInc
Glycosaminoglycan catabolic processIEA:Ensembl
Positive regulation of cellular extravasationManual Assertion Based On ExperimentIDA:UniProtKB
Response to woundingManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane
Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. Localizes at cell-cell junctions.

Topology

Extracellular: 20-238
Helical: 239-259
Cytoplasmic: 260-322

PTM

O-glycosylated.

Anti-LYVE1 antibodies

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-LYVE1 Recombinant Antibody (CBYCL-605) (CBMAB-L0506-YC)

SDS

Target: LYVE1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYCL-605

Application*: E, WB

Mouse Anti-LYVE1 Recombinant Antibody (CBYCL-604) (CBMAB-L0505-YC)

SDS

Target: LYVE1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYCL-604

Application*: F

Mouse Anti-LYVE1 Recombinant Antibody (CBYCL-602) (CBMAB-L0503-YC)

SDS

Target: LYVE1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYCL-602

Application*: E, WB

Rat Anti-Lyve1 Recombinant Antibody (CBYJL-2460) (CBMAB-L2832-YJ)

SDS

Target: Lyve1

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYJL-2460

Application*: WB, P

Rat Anti-Lyve1 Recombinant Antibody (CBYJL-2459) (CBMAB-L2831-YJ)

SDS

Target: Lyve1

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYJL-2459

Application*: WB

Rat Anti-Lyve1 Recombinant Antibody (ALY7) (CBMAB-L2830-YJ)

SDS

Target: Lyve1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: ALY7

Application*: FC, IC, IF, C

Rat Anti-Lyve1 Recombinant Antibody (CBYJL-2457) (CBMAB-L2828-YJ)

SDS

Target: Lyve1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBYJL-2457

Application*: FC

Rat Anti-Lyve1 Recombinant Antibody (CBYJL-2456) (CBMAB-L2827-YJ)

SDS

Target: Lyve1

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYJL-2456

Application*: IH, WB

Rat Anti-Lyve1 Recombinant Antibody (14-4) (CBMAB-L2826-YJ)

SDS

Target: Lyve1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 14-4

Application*: FC, C

Mouse Anti-LYVE1 Recombinant Antibody (CBYJL-2267) (CBMAB-L2531-YJ)

SDS

Target: LYVE1

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYJL-2267

Application*: WB

Mouse Anti-LYVE1 Recombinant Antibody (CBYJL-2265) (CBMAB-L2529-YJ)

SDS

Target: LYVE1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-2265

Application*: E

Mouse Anti-LYVE1 Recombinant Antibody (CBYJL-2262) (CBMAB-L2525-YJ)

SDS

Target: LYVE1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-2262

Application*: F

Mouse Anti-LYVE1 Recombinant Antibody (CBYJL-2261) (CBMAB-L2524-YJ)

SDS

Target: LYVE1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-2261

Application*: B

Mouse Anti-LYVE1 Recombinant Antibody (4G1) (CBMAB-L2523-YJ)

SDS

Target: LYVE1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 4G1

Application*: WB, F, E

Rabbit Anti-LYVE1 Recombinant Antibody (4D17) (CBMAB-L2522-YJ)

SDS

Target: LYVE1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 4D17

Application*: E, IH, WB

Mouse Anti-LYVE1 Recombinant Antibody (CBYJL-2259) (CBMAB-L2520-YJ)

SDS

Target: LYVE1

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYJL-2259

Application*: IH, WB

Mouse Anti-LYVE1 Recombinant Antibody (10K86) (CBMAB-L2519-YJ)

SDS

Target: LYVE1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10K86

Application*: F

Mouse Anti-LYVE1 Recombinant Antibody (CBYJL-2258) (CBMAB-L2518-YJ)

SDS

Target: LYVE1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJL-2258

Application*: E, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

Online Inquiry