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Rabbit Anti-LYVE1 Recombinant Antibody (4D17) (CBMAB-L2522-YJ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
4D17
Antibody Isotype
IgG
Application
ELISA, IHC, WB

Basic Information

Immunogen
LYVE1 antibody was raised in Rabbit using recombinant human soluble LYVE-1 as the immunogen.Immunogen type: Recombinant protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Lymphatic Vessel Endothelial Hyaluronan Receptor 1
Introduction
LYVE1 is a type I integral membrane glycoprotein. LYVE1 acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may play a role in lymphatic hyaluronan transport and have a role in tumor metastasis.
Entrez Gene ID
10894
UniProt ID
Q9Y5Y7
Alternative Names
HAR; XLKD1; LYVE-1; CRSBP-1; lymphatic vessel endothelial hyaluronic acid receptor 1; cell surface retention sequence binding protein-1; extracellular link domain-containing 1; extracellular link domain-containing protein 1; hyaluronic acid receptor
Function
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10037799).
Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (PubMed:26823460).
Biological Process
Anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cell-matrix adhesionManual Assertion Based On ExperimentTAS:ProtInc
Glycosaminoglycan catabolic processIEA:Ensembl
Positive regulation of cellular extravasationManual Assertion Based On ExperimentIDA:UniProtKB
Response to woundingManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. Localizes at cell-cell junctions.
Topology
Extracellular: 20-238
Helical: 239-259
Cytoplasmic: 260-322
PTM
O-glycosylated.
More Infomation

Anstee, J. E., Feehan, K. T., Opzoomer, J. W., Dean, I., Muller, H. P., Bahri, M., ... & Arnold, J. N. (2023). LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer. Developmental Cell, 58(17), 1548-1561.

Burger, F., Baptista, D., Roth, A., Brandt, K. J., da Silva, R. F., Montecucco, F., ... & Miteva, K. (2022). Single-cell RNA-seq reveals a crosstalk between hyaluronan receptor LYVE-1-expressing macrophages and vascular smooth muscle cells. Cells, 11(3), 411.

Kieu, T. Q., Tazawa, K., Kawashima, N., Noda, S., Fujii, M., Nara, K., ... & Okiji, T. (2022). Kinetics of LYVE-1-positive M2-like macrophages in developing and repairing dental pulp in vivo and their pro-angiogenic activity in vitro. Scientific reports, 12(1), 5176.

Jauch, A. S., Wohlfeil, S. A., Weller, C., Dietsch, B., Häfele, V., Stojanovic, A., ... & Géraud, C. (2022). Lyve-1 deficiency enhances the hepatic immune microenvironment entailing altered susceptibility to melanoma liver metastasis. Cancer Cell International, 22(1), 1-17.

Karam, M., Janbon, H., Malkinson, G., & Brunet, I. (2022). Heterogeneity and developmental dynamics of LYVE-1 perivascular macrophages distribution in the mouse brain. Journal of Cerebral Blood Flow & Metabolism, 42(10), 1797-1812.

Sethy, C., Goutam, K., Das, B., Dash, S. R., & Kundu, C. N. (2021). Nectin-4 promotes lymphangiogenesis and lymphatic metastasis in breast cancer by regulating CXCR4-LYVE-1 axis. Vascular Pharmacology, 140, 106865.

Ulndreaj, A., Li, A., Chen, Y., Besla, R., Pacheco, S., Althagafi, M. G., ... & Byrne, J. S. (2021). Adventitial recruitment of Lyve-1− macrophages drives aortic aneurysm in an angiotensin-2-based murine model. Clinical Science, 135(10), 1295-1309.

Brezovakova, V., & Jadhav, S. (2020). Identification of Lyve‐1 positive macrophages as resident cells in meninges of rats. Journal of Comparative Neurology, 528(12), 2021-2032.

Cho, H., Shen, G. Q., Wang, X., Wang, F., Archacki, S., Li, Y., ... & Wang, Q. K. (2019). Long noncoding RNA ANRIL regulates endothelial cell activities associated with coronary artery disease by up-regulating CLIP1, EZR, and LYVE1 genes. Journal of biological chemistry, 294(11), 3881-3898.

Jackson, D. G. (2019). Hyaluronan in the lymphatics: the key role of the hyaluronan receptor LYVE-1 in leucocyte trafficking. Matrix Biology, 78, 219-235.

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For research use only. Not intended for any clinical use.

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