lmn1

Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans.

Full Name

Lamin-1

Function

Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:11071918, PubMed:25057012).
Provides a framework for the nuclear envelope and probably also interacts with chromatin (PubMed:11071918, PubMed:25057012).
Essential to maintain the shape and integrity of the nucleus, and for DNA replication (PubMed:11071918).
Involved in spatial organization of nuclear pore complexes (PubMed:11071918).
It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans (PubMed:12064941).

Biological Process

Determination of adult lifespanManual Assertion Based On ExperimentIMP:UniProtKB
Embryo development ending in birth or egg hatchingManual Assertion Based On ExperimentIMP:UniProtKB
Germ cell developmentManual Assertion Based On ExperimentIMP:WormBase
Nuclear migration along microtubuleManual Assertion Based On ExperimentIMP:WormBase
Nuclear pore localizationManual Assertion Based On ExperimentIMP:WormBase
Nucleus organizationManual Assertion Based On ExperimentIMP:WormBase
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:WormBase
Protein localizationManual Assertion Based On ExperimentIMP:WormBase
Regulation of chromosome segregationManual Assertion Based On ExperimentIMP:WormBase
Regulation of mitotic cell cycleManual Assertion Based On ExperimentIMP:WormBase

Cellular Location

Nucleus envelope
Nucleus inner membrane
Remains in the nuclear envelope until late anaphase in early embryos. Depends on mel-28 for nuclear envelope localization after mitosis.

Anti-lmn1 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-lmn1 Antibody (2G1) (CBMAB-1391CQ)

Datasheet

SDS

Target: lmn1

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: C. elegans, Human

Clone: 2G1

Application*: IF, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)