LIF

LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of neuronal cell differentiation, the induction of hematopoietic differentiation in normal and myeloid leukemia cells, and the stimulation of acute-phase protein synthesis in hepatocytes.

Full Name

Leukemia Inhibitory Factor

Function

LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

Biological Process

Blood vessel remodelingIEA:Ensembl
DecidualizationIEA:Ensembl
Embryo implantationIEA:Ensembl
Immune responseIEA:InterPro
Leukemia inhibitory factor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Lung alveolus developmentIEA:Ensembl
Lung lobe morphogenesisIEA:Ensembl
Lung vasculature developmentIEA:Ensembl
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Muscle organ morphogenesisIEA:Ensembl
Negative regulation of cell population proliferationIEA:Ensembl
Negative regulation of ERK1 and ERK2 cascadeIEA:Ensembl
Negative regulation of hormone secretionManual Assertion Based On ExperimentIDA:MGI
Negative regulation of meiotic nuclear divisionIEA:Ensembl
Neuron developmentIEA:Ensembl
Positive regulation of astrocyte differentiationIEA:Ensembl
Positive regulation of cell adhesion mediated by integrinManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of histone H3-K27 acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage differentiationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:MGI
Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-serine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of protein localization to nucleusManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of metanephric nephron tubule epithelial cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of RNA polymerase II regulatory region sequence-specific DNA bindingIEA:Ensembl
Spongiotrophoblast differentiationIEA:Ensembl
Stem cell differentiationIEA:Ensembl
Stem cell population maintenanceIEA:Ensembl
Trophoblast giant cell differentiationIEA:Ensembl
Tyrosine phosphorylation of STAT proteinIEA:Ensembl

Cellular Location

Secreted

Anti-LIF antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)